Apolipoprotein E4

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  Subject Areas on Research

  • A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. 
  • A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. 
  • A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. 
  • A meta-analysis of genome-wide association studies identifies multiple longevity genes. 
  • A novel Alzheimer disease locus located near the gene encoding tau protein. 
  • A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. 
  • A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. 
  • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. 
  • A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. 
  • A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging. 
  • A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. 
  • APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. 
  • APOE epsilon4 allele carriers: Biological, psychological, and social variables associated with cognitive impairment. 
  • APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample. 
  • APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy. 
  • APOE genotype and hippocampal volume change in geriatric depression. 
  • APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease. 
  • APOE genotype regulates pathology and disease progression in synucleinopathy. 
  • APOE genotype-specific differences in human and mouse macrophage nitric oxide production. 
  • APOE genotype-specific differences in the innate immune response. 
  • APOE related hippocampal shape alteration in geriatric depression. 
  • APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages. 
  • APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies. 
  • APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults. 
  • APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. 
  • APOE ϵ4, rated life experiences, and affect among centenarians. 
  • APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. 
  • APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid. 
  • APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2. 
  • APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. 
  • Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study. 
  • Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan. 
  • Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. 
  • Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects. 
  • Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. 
  • Altered immune responses in apolipoprotein E-deficient mice. 
  • Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice. 
  • Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. 
  • Alzheimer's disease and possible gene interaction. 
  • Amyloid-associated depression and ApoE4 allele: longitudinal follow-up for the development of Alzheimer's disease. 
  • An autosomal genomic screen for dementia in an extended Amish family. 
  • Androgen-mediated immune function is altered by the apolipoprotein E gene. 
  • Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele. 
  • Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. 
  • Apo E structure determines VLDL clearance and atherosclerosis risk in mice. 
  • ApoE genotype-specific inhibition of apoptosis. 
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. 
  • Apolipoprotein E Polymorphism, Cardiac Remodeling, and Heart Failure in the ARIC Study. 
  • Apolipoprotein E alleles and sensorineural hearing loss. 
  • Apolipoprotein E and brain injury: implications for children. 
  • Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. 
  • Apolipoprotein E controls the risk and age at onset of Parkinson disease. 
  • Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition. 
  • Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. 
  • Apolipoprotein E epsilon 4. 
  • Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury. 
  • Apolipoprotein E epsilon4 and risk of mortality in African American and white older community residents. 
  • Apolipoprotein E gene and retinal microvascular signs in older people: the Cardiovascular Health Study. 
  • Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study. 
  • Apolipoprotein E gene polymorphisms are not associated with diabetic retinopathy: the atherosclerosis risk in communities study. 
  • Apolipoprotein E genotype and mortality: findings from the Cache County Study. 
  • Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia. 
  • Apolipoprotein E in Creutzfeldt-Jacob disease. 
  • Apolipoprotein E in Creutzfeldt-Jakob disease. 
  • Apolipoprotein E isoform mediated regulation of nitric oxide release. 
  • Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. 
  • Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. 
  • Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. 
  • Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. 
  • Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults. 
  • Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease. 
  • Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. 
  • Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. 
  • Apolipoprotein E-epsilon 4 frequency in geriatric depression. 
  • Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. 
  • Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. 
  • Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor. 
  • Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. 
  • Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients. 
  • Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. 
  • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. 
  • Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. 
  • Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study. 
  • Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults. 
  • Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample. 
  • Association between APOE epsilon4 allele and vascular dementia: The Cache County study. 
  • Association of ALS with head injury, cigarette smoking and APOE genotypes. 
  • Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study. 
  • Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. 
  • Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. 
  • Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. 
  • Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. 
  • Brain atrophy rates in first degree relatives at risk for Alzheimer's. 
  • Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia. 
  • Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. 
  • Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. 
  • Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models. 
  • Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. 
  • Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants. 
  • Cholesterol and cognitive performance among community volunteers from the Czech Republic. 
  • Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. 
  • Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. 
  • Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. 
  • Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. 
  • Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults. 
  • Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial. 
  • Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele. 
  • Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease. 
  • Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • EFFECT OF THE APOE ε4 ALLELE AND COMBAT EXPOSURE ON PTSD AMONG IRAQ/AFGHANISTAN-ERA VETERANS. 
  • ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. 
  • Early detection of Alzheimer's disease by combining apolipoprotein E and neuroimaging. 
  • Early parental death and late-life dementia risk: findings from the Cache County Study. 
  • Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. 
  • Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression. 
  • Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study. 
  • Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. 
  • Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice. 
  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. 
  • Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease. 
  • Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. 
  • Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging. 
  • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. 
  • Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study. 
  • Genetic susceptibility to Alzheimer disease. 
  • Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk. 
  • Genome-wide scan of copy number variation in late-onset Alzheimer's disease. 
  • High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. 
  • Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration. 
  • Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype. 
  • Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. 
  • Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. 
  • Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. 
  • Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. 
  • Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice. 
  • Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. 
  • Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. 
  • Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition. 
  • Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice. 
  • Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. 
  • Impact of APOE genotype on prion-type propagation of tauopathy. 
  • Impact of APOE in mild cognitive impairment. 
  • Impact of offspring death on cognitive health in late life: the Cache County study. 
  • Influence of Western diet and APOE genotype on Alzheimer's disease risk. 
  • Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. 
  • Inherited frailty. ApoE alleles determine survival after a diagnosis of heart disease or stroke at ages 85+. 
  • Interaction between APOE ε4 and dietary protein intake on cognitive decline: A longitudinal cohort study. 
  • Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. 
  • Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes. 
  • Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. 
  • Investigating Predictors of Cognitive Decline Using Machine Learning. 
  • Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. 
  • Joint effect of stroke and APOE 4 on dementia risk: the Canadian Study of Health and Aging. 
  • Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis. 
  • Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants. 
  • Life experience and demographic influences on cognitive function in older adults. 
  • Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial. 
  • Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease. 
  • Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study. 
  • MAPT rs242557 variant is associated with hippocampus tau uptake on 18F-AV-1451 PET in non-demented elders. 
  • Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth. 
  • Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele. 
  • Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease. 
  • Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. 
  • Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. 
  • Midlife activity predicts risk of dementia in older male twin pairs. 
  • Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease. 
  • Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide. 
  • Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease. 
  • No association between alpha 1-antichymotrypsin and familial Alzheimer's disease. 
  • No association between the HLA-A2 allele and Alzheimer disease. 
  • Occupational exposure to pesticides increases the risk of incident AD: the Cache County study. 
  • Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms. 
  • Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. 
  • Patterns of brain activation in people at risk for Alzheimer's disease. 
  • Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study. 
  • Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data. 
  • Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve. 
  • Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease. 
  • Predictors of cognitive decline after cardiac operation. 
  • Prefrontal activation patterns in subjects at risk for Alzheimer disease. 
  • Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG. 
  • Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives. 
  • Preventing Alzheimer's disease and cognitive decline. 
  • Problems meeting basic needs moderate the association between the APOE epsilon4 allele and cognitive decline. 
  • Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. 
  • Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2. 
  • Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study. 
  • Protein: protein interactions in Alzheimer's disease and the CAG triplet repeat diseases. 
  • Racial differences in the influence of the APOE epsilon 4 allele on cognitive decline in a sample of community-dwelling older adults. 
  • Reduced levels of human apoE4 protein in an animal model of cognitive impairment. 
  • Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease. 
  • Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease. 
  • Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. 
  • Serum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment. 
  • Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline. 
  • Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders. 
  • Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. 
  • Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers. 
  • The APOE-E4 allele and the risk of functional decline in a community sample of African American and white older adults. 
  • The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. 
  • The effects of the apoE4 genotype on the developing mouse retina. 
  • The genetics of dementia in late life. 
  • The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients. 
  • The relationship of APOE genotype to cognitive functioning in older African-American and Caucasian community residents. 
  • The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. 
  • There is a pathologic relationship between ApoE-epsilon 4 and Alzheimer's disease. 
  • Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. 
  • Transethnic genome-wide scan identifies novel Alzheimer's disease loci. 
  • Translocase of outer mitochondrial membrane 40 homolog (TOMM40) poly-T length modulates lorazepam-related cognitive toxicity in healthy APOE ε4-negative elderly. 
  • Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis. 
  • Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele. 
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  Keywords of People

  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Cabeza, Roberto, Professor of Psychology and Neuroscience, Duke Science & Society
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • James, Michael Lucas, Professor of Anesthesiology, Anesthesiology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma