CASP8 and FADD-Like Apoptosis Regulating Protein
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Subject Areas on Research
- A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.
- A role for cFLIP in B cell proliferation and stress MAPK regulation.
- Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo.
- Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.
- An essential role for c-FLIP in the efficient development of mature T lymphocytes.
- Apoptosis and autophagy in the regulation of T lymphocyte function.
- CFLAR/c-FLIPL: a star in the autophagy, apoptosis and necroptosis alliance.
- Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.
- Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells.
- Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells.
- Functional complementation between FADD and RIP1 in embryos and lymphocytes.
- Human RPE expression of cell survival factors.
- Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
- Mind bomb 1 regulation of cFLIP interactions.
- Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.
- Regulation of steady-state neutrophil homeostasis by macrophages.
- The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
- The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.
- The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway.
- c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
- c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway.
- c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo.
- c-FLIP protects mature T lymphocytes from TCR-mediated killing.
- cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis.