Caspases, Initiator

• 

  Subject Areas on Research

  • An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. 
  • Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. 
  • Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. 
  • Caspase-11 protects against bacteria that escape the vacuole. 
  • Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. 
  • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. 
  • Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. 
  • Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. 
  • Investigating the Role of Inflammasome Caspases 1 and 11 in the Acute Radiation Syndrome. 
  • LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro. 
  • Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock. 
  • Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. 
  • Pyroptotic cell death defends against intracellular pathogens. 
  • Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation. 
  • WildCARDs: inflammatory caspases directly detect LPS.