DEAD-box RNA Helicases

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  Subject Areas on Research

  • A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1. 
  • A physical interaction network of dengue virus and human proteins. 
  • Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation. 
  • Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0. 
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. 
  • Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Dynamic microRNA gene transcription and processing during T cell development. 
  • EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome. 
  • G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates. 
  • G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA. 
  • Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique. 
  • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. 
  • Genome-wide association and functional follow-up reveals new loci for kidney function. 
  • HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I. 
  • Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomes. 
  • Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. 
  • Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. 
  • In vivo selection of tumor-targeting RNA motifs. 
  • Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. 
  • Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding. 
  • Novel intronic DICER1 variation associated with pleuropulmonary blastoma in two siblings. 
  • Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. 
  • Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway. 
  • Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development. 
  • Requirement for the vasa RNA helicase in gurken mRNA localization. 
  • Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling. 
  • Role of the Hrp pilus in type III protein secretion in Pseudomonas syringae. 
  • Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. 
  • Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast. 
  • Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. 
  • The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. 
  • The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates. 
  • The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. 
  • The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections. 
  • The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate. 
  • The colorectal microRNAome. 
  • The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato. 
  • The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. 
  • The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. 
  • Unwinding the Wnt action of casein kinase 1. 
  • Use of dominant-negative HrpA mutants to dissect Hrp pilus assembly and type III secretion in Pseudomonas syringae pv. tomato. 
  • Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development. 
  • Visualization of secreted Hrp and Avr proteins along the Hrp pilus during type III secretion in Erwinia amylovora and Pseudomonas syringae. 
  • Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1. 
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  Keywords of People

  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology