Interleukin-1beta

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  Subject Areas on Research

  • 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. 
  • A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing. 
  • A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples. 
  • A noncanonical function of cGAMP in inflammasome priming and activation. 
  • A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation. 
  • Activation of the NLRP3 inflammasome by intracellular poly I:C. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. 
  • Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. 
  • An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage. 
  • Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells. 
  • Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. 
  • Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population. 
  • Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. 
  • Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro. 
  • Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β. 
  • Caspase-1-induced pyroptotic cell death. 
  • Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. 
  • Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia. 
  • Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas. 
  • Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. 
  • DIO2 modifies inflammatory responses in chondrocytes. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. 
  • Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. 
  • Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. 
  • Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia. 
  • Effect of topical azithromycin on corneal innate immune responses. 
  • Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1. 
  • Effects of Lipopolysaccharide on Human First Trimester Villous Cytotrophoblast Cell Function In Vitro. 
  • Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. 
  • Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. 
  • First report of keratitis in familial cold autoinflammatory syndrome. 
  • Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation. 
  • Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats. 
  • Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist. 
  • Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells. 
  • Generation of a Listeria vaccine strain by enhanced caspase-1 activation. 
  • Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis. 
  • Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. 
  • Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. 
  • IFN-beta inhibits human Th17 cell differentiation. 
  • IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage. 
  • IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors. 
  • IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis. 
  • IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity. 
  • Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. 
  • Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. 
  • Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms. 
  • Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. 
  • Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). 
  • Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection. 
  • Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. 
  • Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. 
  • Inflammatory genes and psychological factors predict induced shoulder pain phenotype. 
  • Integrative repair of the meniscus: lessons from in vitro studies. 
  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. 
  • Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population. 
  • Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB. 
  • Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study. 
  • Intestinal alkaline phosphatase decreases intraperitoneal adhesion formation. 
  • Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin. 
  • Just say NO to NLRP3. 
  • Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. 
  • Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. 
  • MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation. 
  • Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. 
  • Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation. 
  • Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes. 
  • Microglia and memory: modulation by early-life infection. 
  • Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats. 
  • Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. 
  • Nociceptors are interleukin-1beta sensors. 
  • Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. 
  • Pancreatic Fluid Interleukin-1β Complements Prostaglandin E2 and Serum Carbohydrate Antigen 19-9 in Prediction of Intraductal Papillary Mucinous Neoplasm Dysplasia. 
  • Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas. 
  • Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation. 
  • Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children. 
  • Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. 
  • Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury. 
  • Programmed necrosis in the cross talk of cell death and inflammation. 
  • Proinflammatory state, hepcidin, and anemia in older persons. 
  • Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats. 
  • Pseudomonas aeruginosa activates caspase 1 through Ipaf. 
  • Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation. 
  • RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms. 
  • Role of interleukin-1beta in postoperative cognitive dysfunction. 
  • Role of mitogen-activated protein kinase in osteoblast differentiation. 
  • Season and size of urban particulate matter differentially affect cytotoxicity and human immune responses to Mycobacterium tuberculosis. 
  • Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes. 
  • Sex differences in microglial colonization of the developing rat brain. 
  • Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation. 
  • Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. 
  • TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation. 
  • TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. 
  • Targeted anti-IL-1β platelet microparticles for cardiac detoxing and repair. 
  • The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. 
  • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. 
  • The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection. 
  • The immune system and developmental programming of brain and behavior. 
  • The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair. 
  • The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury. 
  • Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. 
  • Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. 
  • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. 
  • USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 
  • Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. 
  • Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury. 
  • Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. 
  • Yersinia pestis activates both IL-1β and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague. 
  • β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. 
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  Keywords of People

  • Bilbo, Staci D., Haley Family Professor of Psycology and Neuroscience, Psychology & Neuroscience
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology