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Subject Areas on Research
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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
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A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing.
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A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples.
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A noncanonical function of cGAMP in inflammasome priming and activation.
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A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation.
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Activation of the NLRP3 inflammasome by intracellular poly I:C.
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Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9.
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Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice.
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Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise.
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An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage.
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Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells.
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
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Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population.
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Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms.
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Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro.
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Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β.
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Caspase-1-induced pyroptotic cell death.
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Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome.
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Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury.
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Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration.
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Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia.
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Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules.
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Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.
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Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas.
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Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord.
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DIO2 modifies inflammatory responses in chondrocytes.
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Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
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Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood.
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Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats.
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Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.
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Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia.
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Effect of topical azithromycin on corneal innate immune responses.
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Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.
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Effects of Lipopolysaccharide on Human First Trimester Villous Cytotrophoblast Cell Function In Vitro.
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Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature.
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Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat.
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First report of keratitis in familial cold autoinflammatory syndrome.
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Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
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Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats.
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Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist.
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Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells.
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Generation of a Listeria vaccine strain by enhanced caspase-1 activation.
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Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice.
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Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
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Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis.
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Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.
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Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium.
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IFN-beta inhibits human Th17 cell differentiation.
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IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
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IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors.
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IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.
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IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity.
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Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma.
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Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis.
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Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms.
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Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
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Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
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Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection.
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Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production.
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Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor.
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Inflammatory genes and psychological factors predict induced shoulder pain phenotype.
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Integrative repair of the meniscus: lessons from in vitro studies.
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Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
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Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population.
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Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.
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Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.
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Intestinal alkaline phosphatase decreases intraperitoneal adhesion formation.
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Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin.
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Just say NO to NLRP3.
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Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
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Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.
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MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.
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Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.
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Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.
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Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes.
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Microglia and memory: modulation by early-life infection.
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Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification.
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Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.
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NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats.
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Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
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Nociceptors are interleukin-1beta sensors.
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Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
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Pancreatic Fluid Interleukin-1β Complements Prostaglandin E2 and Serum Carbohydrate Antigen 19-9 in Prediction of Intraductal Papillary Mucinous Neoplasm Dysplasia.
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Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas.
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Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.
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Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children.
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Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
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Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury.
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Programmed necrosis in the cross talk of cell death and inflammation.
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Proinflammatory state, hepcidin, and anemia in older persons.
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Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.
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Pseudomonas aeruginosa activates caspase 1 through Ipaf.
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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.
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RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms.
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Role of interleukin-1beta in postoperative cognitive dysfunction.
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Role of mitogen-activated protein kinase in osteoblast differentiation.
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Season and size of urban particulate matter differentially affect cytotoxicity and human immune responses to Mycobacterium tuberculosis.
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Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes.
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Sex differences in microglial colonization of the developing rat brain.
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Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.
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Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.
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Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.
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Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation.
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TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation.
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TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling.
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Targeted anti-IL-1β platelet microparticles for cardiac detoxing and repair.
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The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
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The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection.
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The immune system and developmental programming of brain and behavior.
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The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair.
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The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury.
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Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
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Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice.
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Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.
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USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.
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Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.
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Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury.
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Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury.
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Yersinia pestis activates both IL-1β and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague.
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β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.
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Keywords of People
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Bilbo, Staci D.,
Haley Family Professor of Psycology and Neuroscience,
Psychology & Neuroscience
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
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Shinohara, Mari L.,
Professor of Integrative Immunobiology,
Cell Biology