Virus Internalization

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  Subject Areas on Research

  • A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation. 
  • A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. 
  • ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry. 
  • An Engineered Biomimetic MPER Peptide Vaccine Induces Weakly HIV Neutralizing Antibodies in Mice. 
  • An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. 
  • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. 
  • Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses. 
  • Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. 
  • Blocking HIV-1 entry by a gp120 surface binding inhibitor. 
  • Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. 
  • Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys. 
  • Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. 
  • Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement. 
  • Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus. 
  • Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. 
  • Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages. 
  • Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. 
  • Design and synthesis of human immunodeficiency virus entry inhibitors: sulfonamide as an isostere for the alpha-ketoamide group. 
  • Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells. 
  • Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles. 
  • Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion. 
  • Estimating the probability of polyreactive antibodies 4E10 and 2F5 disabling a gp41 trimer after T cell-HIV adhesion. 
  • Flavivirus RNA transactions from viral entry to genome replication. 
  • Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. 
  • Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus. 
  • Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders. 
  • Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells. 
  • HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry. 
  • HIV-1 Envelope Conformation, Allostery, and Dynamics. 
  • Heterobiaryl human immunodeficiency virus entry inhibitors. 
  • Immunostimulatory bacterial antigen-armed oncolytic measles virotherapy significantly increases the potency of anti-PD1 checkpoint therapy. 
  • Improving defences at the portal of HIV entry: mucosal and innate immunity. 
  • Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein. 
  • Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. 
  • MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus. 
  • Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • Multifaceted roles for lipids in viral infection. 
  • Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors. 
  • Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. 
  • Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. 
  • Oncolytic polio virotherapy of cancer. 
  • Phenotypic Correlates of HIV-1 Macrophage Tropism. 
  • Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins. 
  • Picornavirus entry. 
  • Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2. 
  • Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1. 
  • Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells. 
  • Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy. 
  • Quinolizidines as Novel SARS-CoV-2 Entry Inhibitors. 
  • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. 
  • Receptor Switching in Newly Evolved Adeno-associated Viruses. 
  • Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. 
  • Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription. 
  • Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. 
  • SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission. 
  • SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement. 
  • Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. 
  • Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. 
  • Structure and immune recognition of trimeric pre-fusion HIV-1 Env. 
  • Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. 
  • Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry. 
  • Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. 
  • Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. 
  • Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins. 
  • The SARS-CoV-2 Spike variant D614G favors an open conformational state. 
  • The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. 
  • The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat. 
  • The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property? 
  • Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography. 
  • Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. 
  • Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7. 
  • Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry. 
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  Keywords of People

  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology