Embryonic Stem Cells

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  Subject Areas on Research

  • A comparative transcriptomic analysis of astrocytes differentiation from human neural progenitor cells. 
  • A controlled-release strategy for the generation of cross-linked hydrogel microstructures. 
  • A conversation with Oliver Smithies. 
  • A shared vision. 
  • A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. 
  • African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast. 
  • An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells. 
  • An early cell shape transition drives evolutionary expansion of the human forebrain. 
  • BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells. 
  • Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. 
  • Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture. 
  • Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas. 
  • Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion. 
  • Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas. 
  • Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. 
  • Controlled differentiation of stem cells. 
  • Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. 
  • Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. 
  • Differentiation of human embryonic stem cells along a hepatic lineage. 
  • Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be? 
  • Directed differentiation and neurite extension of mouse embryonic stem cell on aligned poly(lactide) nanofibers functionalized with YIGSR peptide. 
  • Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. 
  • Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. 
  • Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. 
  • Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes 
  • Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. 
  • Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation. 
  • Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. 
  • Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion. 
  • Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. 
  • Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. 
  • Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes. 
  • High-content imaging-based screening of microenvironment-induced changes to stem cells. 
  • Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology. 
  • Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. 
  • Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC. 
  • Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts. 
  • In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. 
  • In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells. 
  • In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells. 
  • Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors. 
  • Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. 
  • Minireview: Nuclear receptors, hematopoiesis, and stem cells. 
  • Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. 
  • Organoid single cell profiling identifies a transcriptional signature of glomerular disease. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. 
  • Reprogramming after chromosome transfer into mouse blastomeres. 
  • Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. 
  • SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. 
  • Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression. 
  • Specification of chondrocytes and cartilage tissues from embryonic stem cells. 
  • Stem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts. 
  • Summary: present and future challenges for stem cell research. 
  • TBX3 Directs Cell-Fate Decision toward Mesendoderm. 
  • The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. 
  • The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ESC pluripotency. 
  • The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. 
  • The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model of human trophoblast. 
  • The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival. 
  • Therapy with Cardiomyocytes Derived from Pluripotent Cells in Chronic Chagasic Cardiomyopathy. 
  • Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. 
  • Toward a blueprint for regeneration. 
  • Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast. 
  • Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. 
  • Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches. 
  • Vulnerability of primitive human placental trophoblast to Zika virus. 
  • WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs. 
  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. 
  • piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice. 
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  Keywords of People

  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology