Naphthalimides

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  Subject Areas on Research

  • Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. 
  • Hypothalamic CaMKK2 contributes to the regulation of energy balance. 
  • Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. 
  • Phase II study of amonafide in advanced pancreatic adenocarcinoma. 
  • Phase III open-label randomized study of cytarabine in combination with amonafide L-malate or daunorubicin as induction therapy for patients with secondary acute myeloid leukemia. 
  • The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.