Interleukin-2 Receptor alpha Subunit
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Subject Areas on Research
- A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
- Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice.
- Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.
- Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.
- BAFF is increased in renal transplant patients following treatment with alemtuzumab.
- Biologics in organ transplantation.
- CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover.
- CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.
- CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.
- Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
- Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.
- Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
- Denileukin diftitox for the treatment of CD25 low-expression mycosis fungoides and Sézary syndrome.
- ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
- Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
- Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease.
- IL-2-dependent adaptive control of NK cell homeostasis.
- IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
- Immunomodulation of human CD8⁺ T cells by thymoglobulin in vitro.
- Immunosuppressive effects of subglutinol derivatives.
- Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model.
- Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection.
- Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.
- Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome.
- Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells.
- Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
- Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
- Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process.
- Plasma Levels of Soluble Interleukin-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.
- Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.
- Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells.
- Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T cells in patients with malignant glioma reveals differential expression of the immunologic transcriptome compared with T cells from healthy volunteers.
- Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation.
- Regulation of ultraviolet radiation induced cutaneous photoimmunosuppression by toll-like receptor-4.
- Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease.
- Requirement of cognate CD4+ T-cell recognition for the regulation of allospecific CTL by human CD4+ CD127- CD25+ FOXP3+ cells generated in MLR.
- Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.
- Risk alleles for multiple sclerosis identified by a genomewide study.
- Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development.
- Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.
- Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function.
- Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells.
- The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
- The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion.
- The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens.
- Toward effective immunotherapy for the treatment of malignant brain tumors.
- Upregulation of molecules associated with T-regulatory function by thymoglobulin pretreatment of human CD4+ cells.
- Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity.
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Keywords of People
- McLendon, Roger Edwin, Professor of Pathology, Pathology
- Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering