Versicans

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  Subject Areas on Research

  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. 
  • Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan. 
  • Disentangling the genetics of lean mass. 
  • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 
  • Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes. 
  • Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival. 
  • Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology