Metabolic Networks and Pathways
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Subject Areas on Research
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A general map of iron metabolism and tissue-specific subnetworks.
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A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
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A guide to interrogating immunometabolism.
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A roadmap for interpreting (13)C metabolite labeling patterns from cells.
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A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data.
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A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability.
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A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.
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A transcription factor links growth rate and metabolism in the hypersaline adapted archaeon Halobacterium salinarum.
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A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence.
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Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.
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Advances in enzymology and related areas of molecular biology. Preface.
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Alterations in metabolic pathways and networks in Alzheimer's disease.
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Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis.
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An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
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An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer.
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Analysis of Homeostatic Mechanisms in Biochemical Networks.
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Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.
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Application of a label-free, gel-free quantitative proteomics method for ecotoxicological studies of small fish species.
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Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.
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Auxin biosynthesis and storage forms.
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Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.
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CD8+ T cells: mechanistic target of rapamycin and eukaryotic initiation factor 2 in elite HIV-1 control.
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Cancer's insatiable appetite.
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Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
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Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid.
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Cell-Type-Specific Analysis of Molecular Pathology in Autism Identifies Common Genes and Pathways Affected Across Neocortical Regions.
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Cellular arrays for large-scale analysis of transcription factor activity.
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Characterization of the usage of the serine metabolic network in human cancer.
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Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.
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Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer's Disease.
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Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens.
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Comparative proteomic analysis of proteins in response to simulated acid rain in Arabidopsis.
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Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts.
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Conservation of the chitin utilization pathway in the Vibrionaceae.
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Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.
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Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis.
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Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance.
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Design and Analysis of Large-Scale Biological Rhythm Studies: A Comparison of Algorithms for Detecting Periodic Signals in Biological Data
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Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss.
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Dissecting the in vivo metabolic potential of two human gut acetogens.
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Dysfunctional T cell metabolism in the tumor microenvironment.
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Dysregulated metabolism contributes to oncogenesis.
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Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.
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Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study.
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Effect of carbon source addition on toluene biodegradation by an Escherichia coli DH5alpha transconjugant harboring the TOL plasmid.
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Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
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Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.
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Environmental conditions influence the plant functional diversity effect on potential denitrification.
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Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States.
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Ethanol metabolism modifies hepatic protein acylation in mice.
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Evolution of flux control in the glucosinolate pathway in Arabidopsis thaliana
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Evolution of flux control in the glucosinolate pathway in Arabidopsis thaliana.
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Feeding strategy shapes gut metagenomic enrichment and functional specialization in captive lemurs.
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Fine tuning of immunometabolism for the treatment of rheumatic diseases.
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From genotype to phenotype: systems biology meets natural variation.
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Functionality of the TOL plasmid under varying environmental conditions following conjugal transfer.
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GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.
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Gene Expression of Haloferax volcanii on Intermediate and Abundant Sources of Fixed Nitrogen.
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Gene loss and parallel evolution contribute to species difference in flower color.
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Genes, Pathways, and Mechanisms Involved in the Virulence of Mucorales.
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Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.
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Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival.
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Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.
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Genetic variants in glutamine metabolic pathway genes predict cutaneous melanoma-specific survival.
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Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.
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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
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Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates.
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Genomic erosion and extensive horizontal gene transfer in gut-associated Acetobacteraceae.
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Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.
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Genomics and Transcriptomics Analyses of the Oil-Accumulating Basidiomycete Yeast Trichosporon oleaginosus: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating Systems.
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GlpR Is a Direct Transcriptional Repressor of Fructose Metabolic Genes in Haloferax volcanii.
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Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
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Glutamine metabolism during aerial mycelium growth of Neurospora crassa.
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Glyco-engineering in Archaea: differential N-glycosylation of the S-layer glycoprotein in a transformed Haloferax volcanii strain.
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HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
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Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
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Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells.
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Homeostasis and dynamic stability of the phenotype link robustness and plasticity.
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Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma.
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Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis.
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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
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In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.
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Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus.
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Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature.
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Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
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Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.
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Integrated proteomics and metabolomics suggests symbiotic metabolism and multimodal regulation in a fungal-endobacterial system.
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Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease.
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Interplay of Auxin and Cytokinin in Lateral Root Development.
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Investigating the Role of Class I Adenylate-Forming Enzymes in Natural Product Biosynthesis.
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Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.
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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
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Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis.
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Leveraging insights into cancer metabolism-a symposium report.
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MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.
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Mammalian Synthetic Biology: Engineering Biological Systems.
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Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.
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Mathematical analysis of the regulation of competing methyltransferases.
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Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
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Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
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Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease.
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Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth.
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Metabolic Teamwork in the Stem Cell Niche.
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Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.
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Metabolic cycling in control of glucose-stimulated insulin secretion.
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Metabolic decisions in development and disease-a Keystone Symposia report.
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Metabolic division of labor in microbial systems.
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Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders.
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Metabolic network failures in Alzheimer's disease: A biochemical road map.
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Metabolic pathway alterations that support cell proliferation.
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Metabolic profiling of patients with schizophrenia.
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Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.
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Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants.
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Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine.
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Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.
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Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer.
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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
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One-carbon metabolism and epigenetics: understanding the specificity.
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PHGDH amplification and altered glucose metabolism in human melanoma.
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Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli.
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Pathway-based identification of SNPs predictive of survival.
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Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts.
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Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
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PharmGKB summary: methotrexate pathway.
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Pharmacometabolomics reveals racial differences in response to atenolol treatment.
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Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging.
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Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus.
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Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp. nov.
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Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.
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Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept.
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Programmed evolution for optimization of orthogonal metabolic output in bacteria.
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Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism.
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Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking.
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Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.
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Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.
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Quantitative proteome analysis of colorectal cancer-related differential proteins.
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Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium.
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Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.
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Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.
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Reprogramming of cellular metabolic pathways by human oncogenic viruses.
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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
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Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.
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Sleep and metabolism: role of hypothalamic neuronal circuitry.
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SnapShot: Immunometabolism.
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Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.
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Structural and functional analyses of microbial metabolic networks reveal novel insights into genome-scale metabolic fluxes.
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Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.
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Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.
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Testosterone in prostate cancer: the Bethesda consensus.
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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
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The Molecular Link from Diet to Cancer Cell Metabolism.
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The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level.
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The Trait Repertoire Enabling Cyanobacteria to Bloom Assessed through Comparative Genomic Complexity and Metatranscriptomics.
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The evolution of control and distribution of adaptive mutations in a metabolic pathway
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The impact of cellular metabolism on chromatin dynamics and epigenetics.
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The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering.
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The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence.
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The tangled circuitry of metabolism and apoptosis.
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The virulence factor urease and its unexplored role in the metabolism of Cryptococcus neoformans.
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Thermodynamic constraints on the regulation of metabolic fluxes.
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Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
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Transcriptional Regulation in Archaea: From Individual Genes to Global Regulatory Networks.
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Trehalose pathway as an antifungal target.
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Two distinct N-glycosylation pathways process the Haloferax volcanii S-layer glycoprotein upon changes in environmental salinity.
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Understanding metabolism with flux analysis: From theory to application.
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Unprecedented loss of ammonia assimilation capability in a urease-encoding bacterial mutualist.
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Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.
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Use of pathway information in molecular epidemiology.
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Using Strand Displacing Polymerase To Program Chemical Reaction Networks.
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Using isotopic tools to dissect and quantitate parallel metabolic pathways.
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Utility of routine laboratory testing in management of chronic urticaria/angioedema.
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Keywords of People
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Ferguson, P. Lee,
Associate Professor of Civil and Environmental Engineering,
Civil and Environmental Engineering
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Hirschey, Matthew,
Associate Professor of Medicine,
Cell Biology
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Liu, Yutao,
Adjunct Assistant Professor in the Department of Medicine,
Medicine, Medical Genetics
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Pang, Herbert,
Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics,
Biostatistics & Bioinformatics
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Schmid, Amy K.,
David M. Goodner Associate Professor,
Duke Science & Society