Metabolic Networks and Pathways
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Subject Areas on Research
- 2, 6-Diaminopurine as substrate and inhibitor of xanthine oxidase.
- A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
- A roadmap for interpreting (13)C metabolite labeling patterns from cells.
- A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data.
- A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability.
- A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.
- A transcription factor links growth rate and metabolism in the hypersaline adapted archaeon Halobacterium salinarum.
- A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence.
- Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.
- Advances in enzymology and related areas of molecular biology. Preface.
- Alterations in metabolic pathways and networks in Alzheimer's disease.
- An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
- An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer.
- Analysis of Homeostatic Mechanisms in Biochemical Networks.
- Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.
- Application of a label-free, gel-free quantitative proteomics method for ecotoxicological studies of small fish species.
- Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.
- Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.
- Cancer's insatiable appetite.
- Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
- Characterization of the usage of the serine metabolic network in human cancer.
- Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.
- Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens.
- Comparative proteomic analysis of proteins in response to simulated acid rain in Arabidopsis.
- Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts.
- Conservation of the chitin utilization pathway in the Vibrionaceae.
- Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.
- Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis.
- Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data.
- Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss.
- Dissecting the in vivo metabolic potential of two human gut acetogens.
- Dysfunctional T cell metabolism in the tumor microenvironment.
- Dysregulated metabolism contributes to oncogenesis.
- Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.
- Effect of carbon source addition on toluene biodegradation by an Escherichia coli DH5alpha transconjugant harboring the TOL plasmid.
- Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
- Environmental conditions influence the plant functional diversity effect on potential denitrification.
- Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States.
- Ethanol metabolism modifies hepatic protein acylation in mice.
- Evolution of flux control in the glucosinolate pathway in Arabidopsis thaliana.
- Feeding strategy shapes gut metagenomic enrichment and functional specialization in captive lemurs.
- Fine tuning of immunometabolism for the treatment of rheumatic diseases.
- From genotype to phenotype: systems biology meets natural variation.
- Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid.
- Functionality of the TOL plasmid under varying environmental conditions following conjugal transfer.
- Gene loss and parallel evolution contribute to species difference in flower color.
- Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.
- Genomics and Transcriptomics Analyses of the Oil-Accumulating Basidiomycete Yeast Trichosporon oleaginosus: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating Systems.
- Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
- Glutamine metabolism during aerial mycelium growth of Neurospora crassa.
- Glyco-engineering in Archaea: differential N-glycosylation of the S-layer glycoprotein in a transformed Haloferax volcanii strain.
- Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
- Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells.
- Homeostasis and dynamic stability of the phenotype link robustness and plasticity.
- Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma.
- In vivo cytochrome and alternative pathway respiration in leaves of Arabidopsis thaliana plants with altered alternative oxidase under different light conditions.
- In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.
- Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus.
- Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
- Integrated proteomics and metabolomics suggests symbiotic metabolism and multimodal regulation in a fungal-endobacterial system.
- Intermediary purine metabolism and the metabolic defects of gout.
- Into new territory: improved microbial synthesis through engineering of the essential metabolic network.
- Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.
- Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis.
- Mammalian Synthetic Biology: Engineering Biological Systems.
- Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.
- Mathematical analysis of the regulation of competing methyltransferases.
- Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
- Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
- Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth.
- Metabolic Teamwork in the Stem Cell Niche.
- Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.
- Metabolic cycling in control of glucose-stimulated insulin secretion.
- Metabolic division of labor in microbial systems.
- Metabolic network failures in Alzheimer's disease: A biochemical road map.
- Metabolic pathway alterations that support cell proliferation.
- Metabolic profiling of patients with schizophrenia.
- Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.
- Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants.
- Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine.
- Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer.
- Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
- One-carbon metabolism and epigenetics: understanding the specificity.
- PHGDH amplification and altered glucose metabolism in human melanoma.
- Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli.
- Pathway-based identification of SNPs predictive of survival.
- Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts.
- Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
- PharmGKB summary: methotrexate pathway.
- Pharmacometabolomics reveals racial differences in response to atenolol treatment.
- Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus.
- Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept.
- Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism.
- Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking.
- Quantitative proteome analysis of colorectal cancer-related differential proteins.
- Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium.
- Rapid dissection of a complex phenotype through genomic-scale mapping of fitness altering genes.
- SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
- Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.
- SnapShot: Immunometabolism.
- Strategies for the multiplex mapping of genes to traits.
- Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.
- Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.
- Testosterone in prostate cancer: the Bethesda consensus.
- The evolution of control and distribution of adaptive mutations in a metabolic pathway.
- The evolution of genes in branched metabolic pathways.
- The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion.
- The impact of cellular metabolism on chromatin dynamics and epigenetics.
- The neural crest in cardiac congenital anomalies.
- The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering.
- The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence.
- The tangled circuitry of metabolism and apoptosis.
- Thermodynamic constraints on the regulation of metabolic fluxes.
- Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
- Transcriptional Regulation in Archaea: From Individual Genes to Global Regulatory Networks.
- Trehalose pathway as an antifungal target.
- Two distinct N-glycosylation pathways process the Haloferax volcanii S-layer glycoprotein upon changes in environmental salinity.
- Understanding metabolism with flux analysis: From theory to application.
- Unprecedented loss of ammonia assimilation capability in a urease-encoding bacterial mutualist.
- Use of pathway information in molecular epidemiology.
- Using isotopic tools to dissect and quantitate parallel metabolic pathways.
- Utility of routine laboratory testing in management of chronic urticaria/angioedema.
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Keywords of People
- Ferguson, P. Lee, Associate Professor of Civil and Environmental Engineering, Civil and Environmental Engineering
- Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology
- Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
- Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
- Schmid, Amy K., Associate Professor of Biology, Duke Science & Society