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Subject Areas on Research
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Abl kinases are required for invadopodia formation and chemokine-induced invasion.
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Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.
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Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis.
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Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration.
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CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines.
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CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation.
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CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
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CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.
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Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.
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Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells.
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Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
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Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone.
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Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.
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E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
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Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.
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Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.
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G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
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Gene expression profiling of familial and sporadic interstitial pneumonia.
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Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection.
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Genomic correlates of variability in immune response to an oral cholera vaccine.
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HIV envelope gp120 activates human arterial smooth muscle cells.
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Increased transmigration of G-CSF-mobilized peripheral blood CD34+ cells after overnight storage at 37 degrees C.
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Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
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Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.
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Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
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Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism.
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Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.
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Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells.
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Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury.
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MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.
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Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.
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Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes.
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.
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Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.
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Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.
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Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors.
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Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance).
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Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization.
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Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis.
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Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy.
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Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.
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Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.
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Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.
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Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.
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The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
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The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules.
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The impact of pregnancy on anti-HIV activity of cervicovaginal secretions.
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The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases.
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The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury.
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Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
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miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
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Keywords of People
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Pharmacology & Cancer Biology
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Duke Innovation & Entrepreneurship