Receptors, Leptin

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  Subject Areas on Research

  • A novel leptin receptor isoform in rat. 
  • Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function. 
  • Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? 
  • Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis. 
  • Diet-induced obese mice retain endogenous leptin action. 
  • Direct antidiabetic effect of leptin through triglyceride depletion of tissues. 
  • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 
  • Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. 
  • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. 
  • Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. 
  • Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. 
  • Leptin regulates proinflammatory immune responses. 
  • Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. 
  • OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • Peripheral metabolic actions of leptin. 
  • Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. 
  • The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. 
  • The association of gastric leptin with oesophageal inflammation and metaplasia. 
  • Topical lineage-negative progenitor-cell therapy for diabetic wounds. 
  • beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology