Chemokine CX3CL1

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  Subject Areas on Research

  • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. 
  • CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients. 
  • CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. 
  • Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. 
  • IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors. 
  • Immunoengineering nerve repair. 
  • Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. 
  • The chemokine CX3CL1 regulates NK cell activity in vivo. 
  • The homozygous CX3CR1-M280 mutation impairs human monocyte survival. 
  • The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis. 
  • Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology