Ghrelin

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  Subject Areas on Research

  • Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans. 
  • Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans. 
  • Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. 
  • Bariatric Embolization: Pilot Study on the Impact of Gastroprotective Agents and Arterial Distribution on Ulceration Risk and Efficacy in a Porcine Model. 
  • Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model. 
  • Bariatric embolization for suppression of the hunger hormone ghrelin in a porcine model. 
  • Cancer cachexia: Are we ready to take a step forward? 
  • Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. 
  • Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting. 
  • Cholecystokinin. 
  • Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients. 
  • Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. 
  • Dietary macronutrient regulation of acyl and desacyl ghrelin concentrations in children with Prader-Willi syndrome (PWS). 
  • Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus? 
  • Eating disorders and gastrointestinal peptides. 
  • Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. 
  • Effects of ethanol on plasma ghrelin levels in the rat during early and late adolescence. 
  • Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. 
  • Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats. 
  • Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach. 
  • Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats. 
  • Fixed feeding potentiates interdigestive gastric motor activity in rats: importance of eating habits for maintaining interdigestive MMC. 
  • Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1. 
  • Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats. 
  • Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal. 
  • Ghrelin and hypothalamic development: too little and too much of a good thing. 
  • Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development. 
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. 
  • Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2. 
  • Ghrelin receptor signaling in health and disease: a biased view. 
  • Ghrelin regulation of glucose metabolism. 
  • Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans. 
  • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. 
  • Ghrelin, obesity and diabetes. 
  • Histopathologic and immunohistochemical sequelae of bariatric embolization in a porcine model. 
  • Identification and localization of the fatty acid modification in ghrelin by electron capture dissociation. 
  • Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans. 
  • Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice. 
  • Leptin and ghrelin in relation to Helicobacter pylori status in adult males. 
  • Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome. 
  • Mesolimbic exendin-4 attenuates reward salience evoked by neuropeptide Y and ghrelin. 
  • Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: sex differences and the role of growth hormone. 
  • Mice with chronically increased circulating ghrelin develop age-related glucose intolerance. 
  • Mind over milkshakes: mindsets, not just nutrients, determine ghrelin response. 
  • Neural and hormonal regulation of pancreatic secretion. 
  • Obestatin and adropin in Prader-Willi syndrome and nonsyndromic obesity: Associations with weight, BMI-z, and HOMA-IR. 
  • Pediatric narcolepsy. 
  • Pharmacological and surgical treatments for obesity. 
  • Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans. 
  • Physiology of weight loss surgery. 
  • Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients. 
  • Prader Willi Syndrome: Genetics, Metabolomics, Hormonal Function, and New Approaches to Therapy. 
  • Recent advances in pancreatic endocrine and exocrine secretion. 
  • Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia. 
  • The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. 
  • The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. 
  • The intestinal lymph fistula model--a novel approach to study ghrelin secretion. 
  • The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects. 
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  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Page, Laura Caitlin, Assistant Professor of Pediatrics, Pediatrics, Endocrinology