Tissue Scaffolds

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  Subject Areas on Research

  • 2010 Nicolas Andry Award: Multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering. 
  • 3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model. 
  • 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. 
  • 3D Printing: 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. 
  • 3D biofabrication strategies for tissue engineering and regenerative medicine. 
  • A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening. 
  • A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. 
  • A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. 
  • Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. 
  • Active scaffolds for on-demand drug and cell delivery. 
  • Advances in bioengineered conduits for peripheral nerve regeneration. 
  • Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering. 
  • Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. 
  • Anisotropic poly(ethylene glycol)/polycaprolactone hydrogel-fiber composites for heart valve tissue engineering. 
  • Application of hydrogels in heart valve tissue engineering. 
  • Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds. 
  • Biofunctional materials for directing vascular development. 
  • Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction in an immune-competent murine model. 
  • Chemical modification of collagen improves glycosaminoglycan retention of their co-precipitates. 
  • Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. 
  • Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. 
  • Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells. 
  • Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells. 
  • Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production. 
  • Collagen-based fibrous scaffold for spatial organization of encapsulated and seeded human mesenchymal stem cells. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model. 
  • Composite scaffolds for cartilage tissue engineering. 
  • Controlled differentiation of stem cells. 
  • Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels. 
  • Creation of macropores in three-dimensional bacterial cellulose scaffold for potential cancer cell culture. 
  • Deformation and fatigue of tough 3D printed elastomer scaffolds processed by fused deposition modeling and continuous liquid interface production. 
  • Design and validation of a dynamic cell-culture system for bone biology research and exogenous tissue-engineering applications. 
  • Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds. 
  • Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres. 
  • Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. 
  • Dynamic culture yields engineered myocardium with near-adult functional output. 
  • Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds. 
  • Effect of cyclic strain on tensile properties of a naturally derived, decellularized tendon scaffold seeded with allogeneic tenocytes and associated messenger RNA expression. 
  • Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks. 
  • Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells. 
  • Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. 
  • Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models. 
  • Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation. 
  • Engineered skeletal muscle tissue networks with controllable architecture. 
  • Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. 
  • Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes. 
  • Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering. 
  • Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source. 
  • Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering. 
  • Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations. 
  • Fabrication of anatomically-shaped cartilage constructs using decellularized cartilage-derived matrix scaffolds. 
  • Factors influencing the long-term behavior of extracellular matrix-derived scaffolds for musculoskeletal soft tissue repair. 
  • Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. 
  • Functional recordings from awake, behaving rodents through a microchannel based regenerative neural interface. 
  • Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering. 
  • Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. 
  • Genipin-crosslinked cartilage-derived matrix as a scaffold for human adipose-derived stem cell chondrogenesis. 
  • Harnessing localized ridges for high-aspect-ratio hierarchical patterns with dynamic tunability and multifunctionality. 
  • Hyaluronan Hydrogels for a Biomimetic Spongiosa Layer of Tissue Engineered Heart Valve Scaffolds. 
  • Immunoengineering nerve repair. 
  • Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules. 
  • In vitro chondrogenesis of mesenchymal stem cells in recombinant silk-elastinlike hydrogels. 
  • In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds. 
  • In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells. 
  • In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. 
  • Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds. 
  • Influence of diabetes and perivascular allogeneic endothelial cell implants on arteriovenous fistula remodeling. 
  • Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering. 
  • Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering. 
  • Investigation of neovascularization in three-dimensional porous scaffolds in vivo by a combination of multiscale photoacoustic microscopy and optical coherence tomography. 
  • Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. 
  • Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. 
  • Local deformation behavior of surface porous polyether-ether-ketone. 
  • Localization of mesenchymal stem cells grafted with a hyaluronan-based scaffold in the infarcted heart. 
  • Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes. 
  • Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation. 
  • MicroRNA delivery for regenerative medicine. 
  • MicroRNAs in skin tissue engineering. 
  • Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees. 
  • Micropatterning of poly(ethylene glycol) diacrylate hydrogels. 
  • Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells. 
  • Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold. 
  • Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology. 
  • Multicenter phase I/II trial of the safety of allogeneic endothelial cell implants after the creation of arteriovenous access for hemodialysis use: the V-HEALTH study. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Multifunctional hybrid three-dimensionally woven scaffolds for cartilage tissue engineering. 
  • Multilayer microfluidic PEGDA hydrogels. 
  • Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy. 
  • Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease. 
  • PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes. 
  • Perioperative Management of Dual-Antiplatelet Therapy in Patients With New-Generation Drug-Eluting Metallic Stents and Bioresorbable Vascular Scaffolds Undergoing Elective Noncardiac Surgery. 
  • Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions. 
  • Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function. 
  • Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture. 
  • Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2- and 3-dimensions. 
  • Protein-patterned hydrogels: Customized cell microenvironments. 
  • Readily available tissue-engineered vascular grafts. 
  • Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel. 
  • Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers. 
  • Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. 
  • Scaffolding in tissue engineering: general approaches and tissue-specific considerations. 
  • Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis. 
  • Spatial tuning of negative and positive Poisson's ratio in a multi-layer scaffold. 
  • Stem cell-based therapies for osteoarthritis: challenges and opportunities. 
  • Stem cells and cell therapies in lung biology and lung diseases. 
  • Surface tension-assisted additive manufacturing. 
  • Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. 
  • Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. 
  • Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. 
  • The Development of a Xenograft-Derived Scaffold for Tendon and Ligament Reconstruction Using a Decellularization and Oxidation Protocol. 
  • The design of an industry-sponsored randomized controlled trial to compare synthetic mesh versus biologic mesh for inguinal hernia repair. 
  • The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching. 
  • The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. 
  • The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. 
  • This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts. 
  • Tissue engineering of bone: a primer for the practicing hand surgeon. 
  • Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. 
  • Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. 
  • Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. 
  • Transfection in the third dimension. 
  • Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds. 
  • Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials. 
  • Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. 
  • Why Is Infarct Expansion Such an Elusive Therapeutic Target? 
  • [BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit]. 
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  Keywords of People

  • Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering
  • Craig, Stephen L, William T. Miller Professor of Chemistry, Duke University Energy Initiative
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Gall, Ken, Professor in the Department of Mechanical Engineering and Materials Science, Duke Innovation & Entrepreneurship