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Subject Areas on Research
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3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model.
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3D biofabrication strategies for tissue engineering and regenerative medicine.
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A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening.
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A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells.
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A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration.
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A porcine xenograft-derived bone scaffold is a biocompatible bone graft substitute: An assessment of cytocompatibility and the alpha-Gal epitope.
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Accelerated neural differentiation of mouse embryonic stem cells on aligned GYIGSR-functionalized nanofibers.
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Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks
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Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.
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Advances in bioengineered conduits for peripheral nerve regeneration.
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Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering.
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Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing.
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Anisotropic poly(ethylene glycol)/polycaprolactone hydrogel-fiber composites for heart valve tissue engineering.
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Antibacterial efficacy of exogenous nitric oxide on periodontal pathogens.
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Application of hydrogels in heart valve tissue engineering.
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Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease.
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Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds.
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Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation.
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Biofunctional materials for directing vascular development.
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Biomaterializing the promise of cardiac tissue engineering.
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Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction in an immune-competent murine model.
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Cell-Compatible, Site-Specific Covalent Modification of Hydrogel Scaffolds Enables User-Defined Control over Cell-Material Interactions.
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Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells.
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Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells.
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Click by Click Microporous Annealed Particle (MAP) Scaffolds.
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Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production.
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Combining topographical and genetic cues to promote neuronal fate specification in stem cells.
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Compressive anisotropy of sheet and strut based porous Ti-6Al-4V scaffolds.
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Computational Framework to Evaluate the Hydrodynamics of Cell Scaffold Geometries.
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Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.
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Controlled differentiation of stem cells.
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Controlling Particle Fraction in Microporous Annealed Particle Scaffolds for 3D Cell Culture.
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Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels.
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Deformation and fatigue of tough 3D printed elastomer scaffolds processed by fused deposition modeling and continuous liquid interface production.
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Design and Structure-Function Characterization of 3D Printed Synthetic Porous Biomaterials for Tissue Engineering.
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Design and validation of a dynamic cell-culture system for bone biology research and exogenous tissue-engineering applications.
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Design of cell–matrix interactions in hyaluronic acid hydrogel scaffolds
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Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres.
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Dynamic culture yields engineered myocardium with near-adult functional output.
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Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds.
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Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds.
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Effect of cyclic strain on tensile properties of a naturally derived, decellularized tendon scaffold seeded with allogeneic tenocytes and associated messenger RNA expression.
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Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks.
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Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells.
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Effects of Cell-Based Therapy for Treating Tympanic Membrane Perforations in Mice.
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Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering.
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Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models.
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Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.
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Engineered skeletal muscle tissue networks with controllable architecture.
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Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation.
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Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds.
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Enhanced Rotator-Cuff Repair Using Platelet-Rich Plasma Adsorbed on Branched Poly(ester urea)s.
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Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.
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Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies.
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Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes
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Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering.
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Evaluation of culture conditions for in vitro meniscus repair model systems using bone marrow-derived mesenchymal stem cells.
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Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering.
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Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations.
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Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.
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Fatigue behavior of As-built selective laser melted titanium scaffolds with sheet-based gyroid microarchitecture for bone tissue engineering.
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Functional recordings from awake, behaving rodents through a microchannel based regenerative neural interface.
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Functional repair of critically sized femoral defects treated with bioinspired titanium gyroid-sheet scaffolds.
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Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering.
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Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds.
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Gradient versus End-Capped Degradable Polymer Sequence Variations Result in Stiff to Elastic Photochemically 3D-Printed Substrates.
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High-content imaging-based screening of microenvironment-induced changes to stem cells.
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Hyaluronan Hydrogels for a Biomimetic Spongiosa Layer of Tissue Engineered Heart Valve Scaffolds.
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Immunoengineering nerve repair.
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Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules.
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In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.
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In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells.
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In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models.
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Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds
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Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair.
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Influence of Touch-Spun Nanofiber Diameter on Contact Guidance during Peripheral Nerve Repair.
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Influence of diabetes and perivascular allogeneic endothelial cell implants on arteriovenous fistula remodeling.
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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke.
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Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering.
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Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering.
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Investigating the Osteoinductive Potential of a Decellularized Xenograft Bone Substitute.
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Investigation of neovascularization in three-dimensional porous scaffolds in vivo by a combination of multiscale photoacoustic microscopy and optical coherence tomography.
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Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells.
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Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds.
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Local deformation behavior of surface porous polyether-ether-ketone.
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Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes.
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Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair.
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Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects.
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Metabolic glycan labeling and chemoselective functionalization of native biomaterials.
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Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation.
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MicroRNA delivery for regenerative medicine.
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MicroRNAs in skin tissue engineering.
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Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees.
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Microgel-Assisted Delivery of Adenosine to Accelerate Fracture Healing.
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Micropatterning of poly(ethylene glycol) diacrylate hydrogels.
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Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer.
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Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells.
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Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold.
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Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology.
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Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity.
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Modulating Bioglass Concentration in 3D Printed Poly(propylene fumarate) Scaffolds for Post-Printing Functionalization with Bioactive Functional Groups.
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Molecular Mass-Dependent Resorption and Bone Regeneration of 3D Printed PPF Scaffolds in a Critical-Sized Rat Cranial Defect Model.
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Multicenter phase I/II trial of the safety of allogeneic endothelial cell implants after the creation of arteriovenous access for hemodialysis use: the V-HEALTH study.
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Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
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Multilayer microfluidic PEGDA hydrogels.
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Nanotechnologies and regenerative medical approaches for space and terrestrial medicine.
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Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels.
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Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy.
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Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease.
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OGP functionalized phenylalanine-based poly(ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells.
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Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.
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Orthotopic Transplantation of Human Bioartificial Lung Grafts in a Porcine Model: A Feasibility Study.
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PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
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Particle fraction is a bioactive cue in granular scaffolds.
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Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds.
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Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions.
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Photopolymerizable Resins for 3D-Printing Solid-Cured Tissue Engineered Implants.
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Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly(ester urea) Nanofibers.
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Platelet rich plasma concentration improves biologic mesh incorporation and decreases multinucleated giant cells in a dose dependent fashion.
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Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function.
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Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold.
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Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications.
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Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture.
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Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient.
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Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2-and 3-dimensions
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Protein-patterned hydrogels: Customized cell microenvironments.
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Readily available tissue-engineered vascular grafts.
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Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel.
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Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.
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SDF-1 preconditioned HPC scaffolds mobilize cartilage-derived progenitors and stimulate meniscal fibrocartilage repair in human explant tissue culture.
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Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage.
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Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis.
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Spatial tuning of negative and positive Poisson's ratio in a multi-layer scaffold.
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Standardized End Point Definitions for Coronary Intervention Trials: The Academic Research Consortium-2 Consensus Document.
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Stem cells and cell therapies in lung biology and lung diseases.
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Stoichiometric Post-Modification of Hydrogel Microparticles Dictates Neural Stem Cell Fate in Microporous Annealed Particle Scaffolds.
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Structure-property relationships in 3D-printed poly(l-lactide-co-ε-caprolactone) degradable polymer.
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Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues.
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Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds.
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Synthetic ECM: Bioactive Synthetic Hydrogels for 3D Tissue Engineering.
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Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.
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Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain
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The Development of a Xenograft-Derived Scaffold for Tendon and Ligament Reconstruction Using a Decellularization and Oxidation Protocol.
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The design of an industry-sponsored randomized controlled trial to compare synthetic mesh versus biologic mesh for inguinal hernia repair.
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The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching
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The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds.
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The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis.
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The use of optical clearing and multiphoton microscopy for investigation of three-dimensional tissue-engineered constructs
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This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts.
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Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity.
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Tissue engineering of bone: a primer for the practicing hand surgeon.
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Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes.
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Tissue-engineered cartilage with inducible and tunable immunomodulatory properties.
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Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice.
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Transfection in the third dimension
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Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds
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Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials.
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Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels.
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[BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit].
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Keywords of People
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Bursac, Nenad,
Professor of Biomedical Engineering,
Biomedical Engineering
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Craig, Stephen L,
William T. Miller Distinguished Professor of Chemistry,
Nicholas Institute-Energy Initiative
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Gall, Ken,
Professor in the Department of Mechanical Engineering and Materials Science,
Thomas Lord Department of Mechanical Engineering and Materials Science