rho-Associated Kinases
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Subject Areas on Research
- A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
- A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
- A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury.
- A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling.
- Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling.
- Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.
- Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis.
- Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle.
- Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells.
- Corneal Endothelial Cell Migration and Proliferation Enhanced by Rho Kinase (ROCK) Inhibitors in In Vitro and In Vivo Models.
- Current and Emerging Treatment for Diabetic Macular Edema.
- Cyclic mechanical stress and trabecular meshwork cell contractility.
- Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.
- Effects of Y27632 on keratinocyte procurement and wound healing.
- Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma.
- Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.
- Expression levels of mRNA for Rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels.
- Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow.
- Ezrin Orchestrates Signal Transduction in Airway Cells.
- Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
- G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
- Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology.
- Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells.
- Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.
- Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution: Rho Kinase Elevated IOP Treatment Trial (ROCKET-2).
- Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.
- Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells.
- Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
- Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.
- Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.
- Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms.
- Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Three-Month Data from a Randomized Phase 3 Trial.
- PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.
- Phenotypic characterization of murine models of cerebral cavernous malformations.
- Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
- Pooled Efficacy and Safety Profile of Netarsudil Ophthalmic Solution 0.02% in Patients With Open-angle Glaucoma or Ocular Hypertension.
- ROCK1 phosphorylates and activates zipper-interacting protein kinase.
- Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).
- Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
- Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.
- Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.
- Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction.
- Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma.
- Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
- Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration.
- Rho kinase inhibitors for glaucoma treatment - Review.
- Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.
- Rho-kinase inhibitors offer a new approach in the treatment of glaucoma.
- RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
- Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research.
- Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost.
- The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.
- The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate.
- The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase.
- The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
- The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.
- Thrombospondin-1 mediates Rho-kinase inhibitor-induced increase in outflow-facility.
- Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration.
- Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase.
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Keywords of People
- Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute