Phospholipases A2

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  Subject Areas on Research

  • 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. 
  • 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. 
  • A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface. 
  • A novel mechanism of glucocorticosteroid (GC) action in suppression of phospholipase A2 (PLA2) activity stimulated by Ca2+ ionophore A23187: induction of protein phosphatases. 
  • Activation of 85 kDa PLA2 by eicosanoids in human neutrophils and eosinophils. 
  • Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. 
  • Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. 
  • BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. 
  • Ca(2+)-independent arachidonic acid release by vascular endothelium requires protein synthesis de novo. 
  • Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensor. 
  • Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice. 
  • Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming. 
  • Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer. 
  • Components of the protein kinase C pathway induce Ia expression after injection into macrophages. 
  • Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets. 
  • Cooperativity and binding in the mechanism of cytosolic phospholipase A2. 
  • Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. 
  • Cytosolic phospholipase A2 shows burst kinetics consistent with the slow, reversible formation of a dead-end complex. 
  • Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization. 
  • Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols. 
  • Differentiation of U937 cells enables a phospholipase D-dependent pathway of cytosolic phospholipase A2 activation. 
  • Effect of spermine on membranolytic effect of vitamin A in rats. 
  • Effect of temperature on bradykinin-induced arachidonate release and calcium mobilization in vascular endothelial cells. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Evidence for association of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from pancreatic islets and HIT insulinoma cells with a phosphofructokinase-like protein. 
  • Expression, purification, and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2. 
  • Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. 
  • Glucose-responsitivity and expression of an ATP-stimulatable, Ca(2+)-independent phospholipase A2 enzyme in clonal insulinoma cell lines. 
  • Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide. 
  • Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3. 
  • Inhibition of GABA-gated chloride channel function by arachidonic acid. 
  • Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. 
  • Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways. 
  • Leukotriene B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic phospholipase A2. 
  • Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages. 
  • Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2. 
  • Long-term potentiation requires activation of calcium-independent phospholipase A2. 
  • Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. 
  • Mathematical modeling of the Phoenix Rising pathway. 
  • Mechanism of inhibition of human nonpancreatic secreted phospholipase A2 by the anti-inflammatory agent BMS-181162. 
  • Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. 
  • N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways. 
  • Nitric oxide activates the glucose-dependent mobilization of arachidonic acid in a macrophage-like cell line (RAW 264.7) that is largely mediated by calcium-independent phospholipase A2. 
  • Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript. 
  • Phospholipid methylation: a possible mechanism of signal transduction across biomembranes. 
  • Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: requirement for a Gi alpha-type G-protein. 
  • Presence of glycerol masks the effects of phosphorylation on the catalytic efficiency of cytosolic phospholipase A2. 
  • Profile of phospholipase A2 activity in subcellular fractions and lamellar bodies of developing, neonatal and adult rabbit lung. Correlation with intracellular levels of disaturated phosphatidylcholine. 
  • Pulmonary toxicity of trichloroethylene: induction of changes in surfactant phospholipids and phospholipase A2 activity in the mouse lung. 
  • Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation. 
  • Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals. 
  • Regulation of membrane release in apoptosis. 
  • Renaturation of cobra venom phospholipase A2 expressed from a synthetic gene in Escherichia coli. 
  • Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. 
  • Targeting phospholipase A2 for the treatment of inflammatory skin diseases. 
  • The calcium-dependent association and functional coupling of calmodulin with myocardial phospholipase A2. Implications for cardiac cycle-dependent alterations in phospholipolysis. 
  • The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack. 
  • The rapid and reversible association of phosphofructokinase with myocardial membranes during myocardial ischemia. 
  • The size and curvature of anionic covesicle substrate affects the catalytic action of cytosolic phospholipase A2. 
  • cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. 
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  Keywords of People

  • Taylor, Gregory Alan, Professor in Medicine, Immunology