Phospholipases A2
-
Subject Areas on Research
- 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils.
- 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway.
- A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface.
- Activation of 85 kDa PLA2 by eicosanoids in human neutrophils and eosinophils.
- Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules.
- Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.
- Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice.
- Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming.
- Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.
- Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.
- Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols.
- Effect of spermine on membranolytic effect of vitamin A in rats.
- Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators.
- Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells.
- Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3.
- Inhibition of GABA-gated chloride channel function by arachidonic acid.
- Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
- Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways.
- Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages.
- Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.
- Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.
- Mathematical modeling of the Phoenix Rising pathway.
- Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells.
- N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways.
- Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.
- Phospholipid methylation: a possible mechanism of signal transduction across biomembranes.
- Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation.
- Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals.
- Regulation of membrane release in apoptosis.
- Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli.
- The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack.
- cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis.
-
Keywords of People
- Taylor, Gregory Alan, Professor in Medicine, Immunology