Protein Tyrosine Phosphatase, Non-Receptor Type 11
-
Subject Areas on Research
- Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
- Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
- Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
- Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
- Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
- Molecular basis of T cell inactivation by CTLA-4.
- Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase.
- Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.
- SHP-2 is required for the maintenance of cardiac progenitors.
- The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
- Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene.