Subject Areas on Research
- A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure.
- Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.
- Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation.
- Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.
- Targeting VE-PTP phosphatase protects the kidney from diabetic injury.
- Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.
- Treatment of diabetic macular edema with an inhibitor of vascular endothelial-protein tyrosine phosphatase that activates Tie2.