Protein Interaction Domains and Motifs
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Subject Areas on Research
- A Sweet Embrace: Control of Protein-Protein Interactions by O-Linked β-N-Acetylglucosamine.
- A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins.
- A tactile response in Staphylococcus aureus.
- Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).
- Adhesive activity of the haemophilus cryptic genospecies cha autotransporter is modulated by variation in tandem Peptide repeats.
- Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
- Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting.
- Both the conserved GRAS domain and nuclear localization are required for SHORT-ROOT movement.
- Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites.
- Characterization of the CaMKKβ-AMPK signaling complex.
- Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
- Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
- Continuous Interdomain Orientation Distributions Reveal Components of Binding Thermodynamics.
- Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs.
- DOMINE: a comprehensive collection of known and predicted domain-domain interactions.
- DOMINE: a database of protein domain interactions.
- Determinants of Tenascin-C and HIV-1 envelope binding and neutralization.
- Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape.
- Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.
- Distinguishing direct versus indirect transcription factor-DNA interactions.
- Domain-oriented edge-based alignment of protein interaction networks.
- ELF3 is a repressor of androgen receptor action in prostate cancer cells.
- Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC.
- Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase.
- Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.
- Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.
- Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets.
- Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.
- Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.
- Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein-protein interactions directly from DNA.
- Interacting targets of the farnesyl of transducin gamma-subunit.
- Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity.
- Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development.
- Microtubule-driven multimerization recruits ase1p onto overlapping microtubules.
- Molecular insights into DNA binding and anchoring by the Bacillus subtilis sporulation kinetochore-like RacA protein.
- Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ.
- Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.
- Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain.
- Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.
- PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro.
- Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.
- Peptide array X-linking (PAX): a new peptide-protein identification approach.
- Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction.
- Probing structure-function relationships in missense variants in the carboxy-terminal region of BRCA1.
- Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer.
- Quantitation of protein-protein interactions by thermal stability shift analysis.
- RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription.
- Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical-basal polarity establishment.
- Reactive Center Loop Insertion in α-1-Antitrypsin Captured by Accelerated Molecular Dynamics Simulation.
- Real-time heterogeneous protein-protein interaction between αA-crystallin N-terminal mutants and αB-crystallin using quartz crystal microbalance (QCM).
- Restoration of topoisomerase 2 function by complementation of defective monomers in Drosophila.
- Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding.
- Role of co-regulators in metabolic and transcriptional actions of thyroid hormone.
- SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
- Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy.
- Snm1B interacts with PSF2.
- Spliceosomal Prp8 intein at the crossroads of protein and RNA splicing.
- Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations.
- Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein.
- Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients.
- Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin.
- Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation.
- Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.
- Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding.
- Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.
- The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.
- The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
- The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.
- The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor.
- The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.
- The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
- The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.
- TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.
- Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.
- Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).
- Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas.
- WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.
- Zinc finger protein binding to DNA: an energy perspective using molecular dynamics simulation and free energy calculations on mutants of both zinc finger domains and their specific DNA bases.
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Keywords of People
- Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
- Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
- Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology