Calcium-Calmodulin-Dependent Protein Kinase Kinase
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Subject Areas on Research
- A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation.
- Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.
- BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.
- CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.
- Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.
- Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
- Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.
- Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.
- Characterization of the CaMKKβ-AMPK signaling complex.
- Chutes and Ladders: the search for protein kinases that act on AMPK.
- Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.
- Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation.
- Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
- Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.
- Hypothalamic CaMKK2 contributes to the regulation of energy balance.
- Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.
- Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.
- Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.
- Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.
- Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.
- Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism.
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Keywords of People
- McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
- Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology