G-Protein-Coupled Receptor Kinases
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Subject Areas on Research
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Arrestins come of age: a personal historical perspective.
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Beta-arrestins: multifunctional cellular mediators.
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Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells.
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Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.
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Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling.
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Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
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Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
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Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.
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Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
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Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization.
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G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
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G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
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G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.
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G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.
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G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.
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Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).
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Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.
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Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
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Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors.
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Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
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Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
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Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.
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Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.
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Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands.
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Seven transmembrane receptors: something old, something new.
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The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.
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The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes.
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The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas.
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The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.
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Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF.
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beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
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beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.
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β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.