Small Molecule Libraries

• 

  Subject Areas on Research

  • A small molecule inhibitor of alpha4 integrin-dependent cell migration. 
  • A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. 
  • A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. 
  • Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. 
  • An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. 
  • Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. 
  • Chemical interrogation of the malaria kinome. 
  • Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells. 
  • Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. 
  • Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. 
  • Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Discovery of Dual-Stage Malaria Inhibitors with New Targets. 
  • Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands. 
  • Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold. 
  • Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics. 
  • Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy. 
  • Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. 
  • Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. 
  • Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. 
  • Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA. 
  • Guanine analogues enhance antisense oligonucleotide-induced exon skipping in dystrophin gene in vitro and in vivo. 
  • High throughput screening for neurodegeneration and complex disease phenotypes. 
  • High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble. 
  • Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. 
  • Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse. 
  • Identification of repurposed small molecule drugs for chordoma therapy. 
  • Identifying new small molecule anti-invasive compounds for glioma treatment. 
  • Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules. 
  • Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. 
  • Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. 
  • Insights into the development of chemical probes for RNA. 
  • Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis. 
  • PAK1 mediates resistance to PI3K inhibition in lymphomas. 
  • Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. 
  • Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. 
  • Preclinical Development of New Therapy for Glycogen Storage Diseases. 
  • RNA Structural Differentiation: Opportunities with Pattern Recognition. 
  • Role of natural product diversity in chemical biology. 
  • Sensing the impact of environment on small molecule differentiation of RNA sequences. 
  • Small Molecule-Based Pattern Recognition To Classify RNA Structure. 
  • Small molecule modulators of Wnt/β-catenin signaling. 
  • Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries. 
  • Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. 
  • Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. 
  • Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds. 
  • Stopping cancer in its tracks: using small molecular inhibitors to target glioblastoma migrating cells. 
  • Strategy to discover diverse optimal molecules in the small molecule universe. 
  • Targeting RNA in mammalian systems with small molecules. 
  • The end game of chemical genetics: target identification. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
  • WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.