Small Molecule Libraries
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Subject Areas on Research
- A small molecule inhibitor of alpha4 integrin-dependent cell migration.
- A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra.
- A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.
- Advanced Editorial to announce a JCAMD Special Issue on Artificial Intelligence and Machine Learning.
- Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
- Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer.
- An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL.
- Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
- Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.
- Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade.
- Chemical interrogation of the malaria kinome.
- Computational advances in combating colloidal aggregation in drug discovery.
- Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor.
- Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors.
- Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors.
- Differentiation and classification of RNA motifs using small molecule-based pattern recognition.
- Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule.
- Discovery and characterization of small molecules that target the GTPase Ral.
- Discovery of Dual-Stage Malaria Inhibitors with New Targets.
- Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.
- Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.
- Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.
- Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.
- Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy.
- Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation.
- Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.
- Driving factors in amiloride recognition of HIV RNA targets.
- Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
- Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA.
- Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA.
- Fragment-Based Deā Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA.
- Frameworks for targeting RNA with small molecules.
- High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.
- Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.
- Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.
- Identification of repurposed small molecule drugs for chordoma therapy.
- Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities.
- Identifying new small molecule anti-invasive compounds for glioma treatment.
- Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.
- Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.
- Inhibitor of apoptosis proteins as intracellular signaling intermediates.
- Insights into the development of chemical probes for RNA.
- Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening.
- New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.
- PAK1 mediates resistance to PI3K inhibition in lymphomas.
- Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
- Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
- Population pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors.
- Preclinical Development of New Therapy for Glycogen Storage Diseases.
- Psychedelic-inspired drug discovery using an engineered biosensor.
- R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures.
- RNA Structural Differentiation: Opportunities with Pattern Recognition.
- Role of natural product diversity in chemical biology.
- Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.
- Sensing the impact of environment on small molecule differentiation of RNA sequences.
- Small Molecule-Based Pattern Recognition To Classify RNA Structure.
- Small molecule modulators of Wnt/β-catenin signaling.
- Small molecule targeting of biologically relevant RNA tertiary and quaternary structures.
- Small molecule-RNA targeting: starting with the fundamentals.
- Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.
- Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.
- Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds.
- Strategy to discover diverse optimal molecules in the small molecule universe.
- Structural basis for μ-opioid receptor binding and activation.
- Targeting RNA in mammalian systems with small molecules.
- Targeting RNA with small molecules: from fundamental principles towards the clinic.
- The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans.
- The end game of chemical genetics: target identification.
- Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions.
- Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays.
- Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
- Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules.
- WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.
- Zebrafish developmental screening of the ToxCast™ Phase I chemical library.
- β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.