Small Molecule Libraries

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  Subject Areas on Research

  • A small molecule inhibitor of alpha4 integrin-dependent cell migration. 
  • A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. 
  • A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. 
  • Advanced Editorial to announce a JCAMD Special Issue on Artificial Intelligence and Machine Learning. 
  • Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. 
  • Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. 
  • An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. 
  • Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. 
  • Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity. 
  • Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade. 
  • Chemical interrogation of the malaria kinome. 
  • Computational advances in combating colloidal aggregation in drug discovery. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors. 
  • Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. 
  • Differentiation and classification of RNA motifs using small molecule-based pattern recognition. 
  • Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Discovery of Dual-Stage Malaria Inhibitors with New Targets. 
  • Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands. 
  • Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold. 
  • Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays. 
  • Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics. 
  • Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy. 
  • Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. 
  • Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. 
  • Driving factors in amiloride recognition of HIV RNA targets. 
  • Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. 
  • Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA. 
  • Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA. 
  • Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA. 
  • Frameworks for targeting RNA with small molecules. 
  • High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble. 
  • Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse. 
  • Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening. 
  • Identification of repurposed small molecule drugs for chordoma therapy. 
  • Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities. 
  • Identifying new small molecule anti-invasive compounds for glioma treatment. 
  • Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules. 
  • Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. 
  • Inhibitor of apoptosis proteins as intracellular signaling intermediates. 
  • Insights into the development of chemical probes for RNA. 
  • Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening. 
  • New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. 
  • PAK1 mediates resistance to PI3K inhibition in lymphomas. 
  • Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. 
  • Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. 
  • Population pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors. 
  • Preclinical Development of New Therapy for Glycogen Storage Diseases. 
  • Psychedelic-inspired drug discovery using an engineered biosensor. 
  • R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures. 
  • RNA Structural Differentiation: Opportunities with Pattern Recognition. 
  • Role of natural product diversity in chemical biology. 
  • Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. 
  • Sensing the impact of environment on small molecule differentiation of RNA sequences. 
  • Small Molecule-Based Pattern Recognition To Classify RNA Structure. 
  • Small molecule modulators of Wnt/β-catenin signaling. 
  • Small molecule targeting of biologically relevant RNA tertiary and quaternary structures. 
  • Small molecule-RNA targeting: starting with the fundamentals. 
  • Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries. 
  • Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. 
  • Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds. 
  • Strategy to discover diverse optimal molecules in the small molecule universe. 
  • Structural basis for μ-opioid receptor binding and activation. 
  • Targeting RNA in mammalian systems with small molecules. 
  • Targeting RNA with small molecules: from fundamental principles towards the clinic. 
  • The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans. 
  • The end game of chemical genetics: target identification. 
  • Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions. 
  • Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
  • Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules. 
  • WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. 
  • Zebrafish developmental screening of the ToxCast™ Phase I chemical library. 
  • β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.