Small Molecule Libraries
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Subject Areas on Research
- A small molecule inhibitor of alpha4 integrin-dependent cell migration.
- A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra.
- A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.
- Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
- Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
- Chemical interrogation of the malaria kinome.
- Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions.
- Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor.
- Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.
- Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors.
- Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule.
- Discovery and characterization of small molecules that target the GTPase Ral.
- Discovery of Dual-Stage Malaria Inhibitors with New Targets.
- Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.
- Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.
- Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy.
- Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation.
- Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.
- Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
- Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA.
- High throughput screening for neurodegeneration and complex disease phenotypes.
- Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.
- Identification of repurposed small molecule drugs for chordoma therapy.
- Identifying new small molecule anti-invasive compounds for glioma treatment.
- Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.
- Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.
- Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.
- Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis.
- PAK1 mediates resistance to PI3K inhibition in lymphomas.
- Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
- Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
- Preclinical Development of New Therapy for Glycogen Storage Diseases.
- Role of natural product diversity in chemical biology.
- Sensing the impact of environment on small molecule differentiation of RNA sequences.
- Small Molecule-Based Pattern Recognition To Classify RNA Structure.
- Small molecule modulators of Wnt/β-catenin signaling.
- Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.
- Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.
- Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds.
- Strategy to discover diverse optimal molecules in the small molecule universe.
- Targeting RNA in mammalian systems with small molecules.
- The end game of chemical genetics: target identification.
- Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
- WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.