Ubiquitination

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  Subject Areas on Research

  • A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. 
  • A special issue on TGF-beta signaling. 
  • Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. 
  • Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice. 
  • Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling. 
  • Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. 
  • Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. 
  • Application of immobilized ATP to the study of NLRP inflammasomes. 
  • Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. 
  • Arrestins and protein ubiquitination. 
  • Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. 
  • Caspases and IAPs: a dance of death ensures cell survival. 
  • Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. 
  • Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination. 
  • Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors. 
  • Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. 
  • Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase. 
  • Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C-Terminus of Hsc70 Interacting Protein (CHIP). 
  • Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. 
  • Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks. 
  • Control of cellular GADD34 levels by the 26S proteasome. 
  • Control of electrolyte balance through ubiquitination. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. 
  • Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET. 
  • Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. 
  • Deubiquitinases and their emerging roles in β-arrestin-mediated signaling. 
  • Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. 
  • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells. 
  • Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. 
  • E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. 
  • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. 
  • Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. 
  • Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response. 
  • Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. 
  • GPCR desensitization: Acute and prolonged phases. 
  • Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis. 
  • Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy? 
  • In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. 
  • Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. 
  • Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles. 
  • Intrinsic disorder drives N-terminal ubiquitination by Ube2w. 
  • Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling. 
  • K63 polyubiquitination is a new modulator of the oxidative stress response. 
  • Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. 
  • LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. 
  • Lysine modifications and autophagy. 
  • MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis. 
  • Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. 
  • Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. 
  • Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition. 
  • Methed-up FOXOs can't in-Akt-ivate. 
  • Mind bomb 1 regulation of cFLIP interactions. 
  • Mitochondrial dynamics and Parkinson's disease: focus on parkin. 
  • Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. 
  • Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP. 
  • MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. 
  • Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. 
  • Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. 
  • Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons. 
  • Not-so-pseudo a substrate: Acm1-mediated inhibition of the APC. 
  • O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. 
  • Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. 
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. 
  • Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages. 
  • Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. 
  • PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination. 
  • Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. 
  • Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation. 
  • Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer. 
  • Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. 
  • Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. 
  • Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. 
  • Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases. 
  • Programmed necrosis in the cross talk of cell death and inflammation. 
  • Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. 
  • Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. 
  • Proteomic analysis of the NOS2 interactome in human airway epithelial cells. 
  • Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. 
  • Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes. 
  • Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. 
  • Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome. 
  • Regulation of inflammation by β-arrestins: Not just receptor tales. 
  • Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. 
  • Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. 
  • Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. 
  • Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription. 
  • SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. 
  • SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis. 
  • SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. 
  • SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. 
  • Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control. 
  • Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress. 
  • Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. 
  • Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation. 
  • Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets. 
  • Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase. 
  • Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. 
  • TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). 
  • The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. 
  • The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. 
  • The N-Terminal UND Motif of the Arabidopsis U-Box E3 Ligase PUB18 Is Critical for the Negative Regulation of ABA-Mediated Stomatal Movement and Determines Its Ubiquitination Specificity for Exocyst Subunit Exo70B1. 
  • The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications. 
  • The Skp2 Pathway: A Critical Target for Cancer Therapy. 
  • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 
  • The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. 
  • The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction. 
  • The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. 
  • The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling. 
  • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 
  • The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. 
  • The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP. 
  • The molecular regulation of programmed necrotic cell injury. 
  • The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. 
  • Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. 
  • Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation. 
  • USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 
  • USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. 
  • USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. 
  • UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP. 
  • Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. 
  • Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction. 
  • Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. 
  • Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation. 
  • Ubiquitination and filamentous structure of cytidine triphosphate synthase. 
  • Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex. 
  • Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. 
  • Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation. 
  • Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. 
  • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 
  • Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
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  Keywords of People

  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology