Host-Pathogen Interactions

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  Subject Areas on Research

  • A Zebrafish Model of Cryptococcal Infection Reveals Roles for Macrophages, Endothelial Cells, and Neutrophils in the Establishment and Control of Sustained Fungemia. 
  • A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization. 
  • A highway for war and peace: the secretory pathway in plant-microbe interactions. 
  • A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. 
  • A miRNA-responsive cell-free translation system facilitates isolation of hepatitis C virus miRNP complexes. 
  • A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. 
  • A novel diagnostic approach may reduce inappropriate antibiotic use for acute respiratory infections. 
  • A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy. 
  • A physical interaction network of dengue virus and human proteins. 
  • A power-law dependence of bacterial invasion on mammalian host receptors. 
  • AIDS/HIV. Host controls of HIV neutralizing antibodies. 
  • Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. 
  • Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. 
  • Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group. 
  • An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. 
  • Analysis of the mRNA targetome of microRNAs expressed by Marek's disease virus. 
  • Analysis of the real EADGENE data set: multivariate approaches and post analysis (open access publication). 
  • Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development. 
  • Antiretroviral restriction factors in mice. 
  • Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae. 
  • Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses. 
  • Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. 
  • Asthma and the host-microbe interaction. 
  • Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis. 
  • Battle for survival: plants and their allies and enemies. 
  • Biochemistry and Molecular Biology of Flaviviruses. 
  • CD4 T follicular helper cell dynamics during SIV infection. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. 
  • Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. 
  • Cell biology at the host-microbe interface. 
  • Cellular fatty acid synthase is required for late stages of HIV-1 replication. 
  • Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. 
  • Characterization of the EBV-Induced Persistent DNA Damage Response. 
  • Chemoenzymatic Assembly of Bacterial Glycoconjugates for Site-Specific Orthogonal Labeling. 
  • Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. 
  • Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. 
  • Chlamydial intracellular survival strategies. 
  • Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. 
  • Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. 
  • Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance? 
  • Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. 
  • Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment. 
  • Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). 
  • Convergent evolution of escape from hepaciviral antagonism in primates. 
  • Copper at the Fungal Pathogen-Host Axis. 
  • Copper at the front line of the host-pathogen battle. 
  • Copper in microbial pathogenesis: meddling with the metal. 
  • Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. 
  • Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. 
  • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. 
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. 
  • Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier. 
  • Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition. 
  • Defining the interaction of HIV-1 with the mucosal barriers of the female reproductive tract. 
  • Detection of viruses via statistical gene expression analysis. 
  • Development of fungal applications on netting substrates for malaria vector control. 
  • Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge. 
  • Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. 
  • Discovery of insect and human dengue virus host factors. 
  • Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation. 
  • Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi. 
  • Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. 
  • Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. 
  • Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing. 
  • Emancipating Chlamydia: Advances in the Genetic Manipulation of a Recalcitrant Intracellular Pathogen. 
  • Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack. 
  • Emerging roles for lipid droplets in immunity and host-pathogen interactions. 
  • Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB. 
  • Engineering AAV receptor footprints for gene therapy. 
  • Engineering of obligate intracellular bacteria: progress, challenges and paradigms. 
  • Environmentally controlled bacterial vesicle-mediated export. 
  • Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication. 
  • Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. 
  • Evaluating the Impact of Functional Genetic Variation on HIV-1 Control. 
  • Evaluating the impacts of multiple generalist fungal pathogens on temperate tree seedling survival. 
  • Evidence for transovarial transmission of tick-borne rickettsiae circulating in Northern Mongolia. 
  • Evolution of host range in Coleosporium ipomoeae, a plant pathogen with multiple hosts. 
  • Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications? 
  • Flaviviral RNAs: weapons and targets in the war between virus and host. 
  • Flavivirus RNA transactions from viral entry to genome replication. 
  • Functional Advantages of Porphyromonas gingivalis Vesicles. 
  • Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. 
  • Fungi that Infect Humans. 
  • G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. 
  • GATA transcription factor required for immunity to bacterial and fungal pathogens. 
  • Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft. 
  • Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. 
  • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 
  • Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans. 
  • Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture. 
  • Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses. 
  • Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. 
  • Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. 
  • HIV-1 autoreactive antibodies: are they good or bad for HIV-1 prevention? 
  • HIV-Host Interactions: Implications for Vaccine Design. 
  • Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques. 
  • Hijacked: Co-option of host behavior by entomophthoralean fungi. 
  • Host cell transcriptome profile during wild-type and attenuated dengue virus infection. 
  • Host controls of HIV broadly neutralizing antibody development. 
  • Host defenses against cryptococcosis. 
  • Host gene expression classifiers diagnose acute respiratory illness etiology. 
  • Host genetics and HIV-1: the final phase? 
  • Host-Directed Therapies for Tuberculosis. 
  • Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction. 
  • Host-microbe interactions in the developing zebrafish. 
  • Host-microbe interactions: bacteria. 
  • Human genome-wide RNAi screen for host factors that modulate intracellular Salmonella growth. 
  • Identification and comparative analysis of hepatitis C virus-host cell protein interactions. 
  • Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. 
  • Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication. 
  • Identification of a Lineage D Betacoronavirus in Cave Nectar Bats (Eonycteris spelaea) in Singapore and an Overview of Lineage D Reservoir Ecology in SE Asian Bats. 
  • Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus. 
  • Identification of cell cycle-regulated, putative hyphal genes in Candida albicans. 
  • Identification of early interactions between Francisella and the host. 
  • Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti. 
  • In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms. 
  • Increasing the potential for malaria elimination by targeting zoophilic vectors. 
  • Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase. 
  • Infection-Induced Vascular Permeability Aids Mycobacterial Growth. 
  • Infectious disease models in zebrafish. 
  • Influenza A virus-derived siRNAs increase in the absence of NS1 yet fail to inhibit virus replication. 
  • Inhibition of apoptosis by Rv2456c through Nuclear factor-κB extends the survival of Mycobacterium tuberculosis. 
  • Innate immune evasion strategies of DNA and RNA viruses. 
  • Interactions between a fungal entomopathogen and malaria parasites within a mosquito vector. 
  • Intersection of salt- and immune-mediated mechanisms of hypertension in the gut microbiome. 
  • Invasive mycoses: evolving challenges and opportunities in antifungal therapy (multimedia activity). 
  • Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. 
  • Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs. 
  • Know your enemy: how to build and vanquish a global fungal scourge. 
  • Leading a sheltered life: intracellular pathogens and maintenance of vacuolar compartments. 
  • Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts. 
  • Linking environmental nutrient enrichment and disease emergence in humans and wildlife. 
  • Lipids at the interface of virus-host interactions. 
  • Live Imaging of Host-Pathogen Interactions in Zebrafish Larvae. 
  • MAVS Coordination of Antiviral Innate Immunity. 
  • Making sense of hormone crosstalk during plant immune responses. 
  • Metatranscriptomic Study of Common and Host-Specific Patterns of Gene Expression between Pines and Their Symbiotic Ectomycorrhizal Fungi in the Genus Suillus. 
  • Microparasites and Placental Invasiveness in Eutherian Mammals. 
  • Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections. 
  • Modeling phage induced bacterial disinfection rates and the resulting design implications. 
  • Models to study ancient host-pathogen interactions: lessons from Crete. 
  • Multifaceted roles for lipids in viral infection. 
  • N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. 
  • New insights into Chlamydia intracellular survival mechanisms. 
  • Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection. 
  • Offense and defense: microbial membrane vesicles play both ways. 
  • Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection. 
  • Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. 
  • Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells. 
  • Post-translational regulation of plant immunity. 
  • Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells. 
  • RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein Accumulation. 
  • Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches. 
  • Regulation of hepatic innate immunity by hepatitis C virus. 
  • Remaining flexible in old alliances: functional plasticity in constrained mutualisms. 
  • Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments. 
  • Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs. 
  • Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness. 
  • Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans. 
  • Roles of Pro-viral Host Factors in Mosquito-Borne Flavivirus Infections. 
  • Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells. 
  • Sequential utilization of hosts from different fly families by genetically distinct, sympatric populations within the Entomophthora muscae species complex. 
  • Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States. 
  • Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome. 
  • Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection. 
  • Spore persistence and likelihood of aeroallergenicity of entomopathogenic fungi used for mosquito control. 
  • Staufen1 Interacts with Multiple Components of the Ebola Virus Ribonucleoprotein and Enhances Viral RNA Synthesis. 
  • Staying alive: cell death in antiviral immunity. 
  • Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins. 
  • Study of host-microbe interactions in zebrafish. 
  • Surfactant protein D facilitates Cryptococcus neoformans infection. 
  • Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility. 
  • TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. 
  • Targeting host factors to treat West Nile and dengue viral infections. 
  • Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells. 
  • The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish. 
  • The current epidemiology and clinical decisions surrounding acute respiratory infections. 
  • The host response: Toll-like receptor expression in periprosthetic tissues as a biomarker for deep joint infection. 
  • The macroecology of infectious diseases: a new perspective on global-scale drivers of pathogen distributions and impacts. 
  • The nature of immune responses to urinary tract infections. 
  • The oral microbiome in health and disease and the potential impact on personalized dental medicine. 
  • The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack. 
  • The role of dynamin in HIV type 1 Env-mediated cell-cell fusion. 
  • The role of microRNAs in Epstein-Barr virus latency and lytic reactivation. 
  • The role of natural killer (NK) cells and NK cell receptor polymorphisms in the assessment of HIV-1 neutralization. 
  • The role of the granuloma in expansion and dissemination of early tuberculous infection. 
  • Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. 
  • Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection. 
  • Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans. 
  • Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii. 
  • Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7. 
  • Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection. 
  • Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
  • Viral substitution rate variation can arise from the interplay between within-host and epidemiological dynamics. 
  • Virulence and immunomodulatory roles of bacterial outer membrane vesicles. 
  • Virulence mechanisms and Cryptococcus neoformans pathogenesis. 
  • Virulence profile: Alejandro Aballay. 
  • Viruses, microRNAs, and host interactions. 
  • What was old is new again: using the host response to diagnose infectious disease. 
  • Zebrafish and frog models of Mycobacterium marinum infection. 
  • Zebrafish: a see-through host and a fluorescent toolbox to probe host-pathogen interaction. 
  • Zika virus: History, emergence, biology, and prospects for control. 
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  Keywords of People

  • Horner, Stacy M., Assistant Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology
  • McClain, Micah Thomas, Associate Professor of Medicine, Medicine, Infectious Diseases
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology
  • Tobin, David M., Associate Professor of Molecular Genetics and Microbiology, Immunology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology