Optics and Photonics

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  Subject Areas on Research

  • 6450 nm wavelength tissue ablation using a nanosecond laser based on difference frequency mixing and stimulated Raman scattering. 
  • A dynamic broadband reflector built from microscopic silica spheres in the 'disco' clam Ctenoides ales. 
  • A hyperspectral imaging system for in vivo optical diagnostics. Hyperspectral imaging basic principles, instrumental systems, and applications of biomedical interest. 
  • A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes. 
  • Advanced imaging and technology in gastrointestinal neoplasia: summary of the AGA-NCI Symposium October 4-5, 2004. 
  • Amplification of optical delay by use of matched linearly chirped fiber Bragg gratings. 
  • Application of Mie theory to assess structure of spheroidal scattering in backscattering geometries. 
  • Argon laser retinal lesions evaluated in vivo by optical coherence tomography. 
  • Autocorrelation artifacts in optical coherence tomography and interferometric synthetic aperture microscopy. 
  • Autofocus algorithm for dispersion correction in optical coherence tomography. 
  • Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation. 
  • Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. 
  • Broadband gradient index microwave quasi-optical elements based on non-resonant metamaterials. 
  • Broadband optical antireflection enhancement by integrating antireflective nanoislands with silicon nanoconical-frustum arrays. 
  • Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle. 
  • Characterization of novel microsphere chain fiber optic tips for potential use in ophthalmic laser surgery. 
  • Chip-scale sensor system integration for portable health monitoring. 
  • Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics. 
  • Compressive holography. 
  • Correlation of intrinsic optical signal, cerebral blood flow, and evoked potentials during activation of rat somatosensory cortex. 
  • Cryptic and conspicuous coloration in the pelagic environment. 
  • Design of an acoustic metamaterial lens using genetic algorithms. 
  • Detection of cytochrome C in a single cell using an optical nanobiosensor. 
  • Development of a fluorescence detection system using optical parametric oscillator (OPO) laser excitation for in vivo diagnosis. 
  • Differential pathlength factor for diffuse photon scattering through tissue by a pulse-response method. 
  • Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. 
  • Direct Optical Imaging of Graphene In Vitro by Nonlinear Femtosecond Laser Spectral Reshaping 
  • Dual-band planar electric metamaterial in the terahertz regime. 
  • Effects of pulse shaping in laser spectroscopy and nuclear magnetic resonance. 
  • Electrode systems for measuring cardiac impedances using optical transmembrane potential sensors and interstitial electrodes--theoretical design. 
  • Electron microscopy of thin filaments decorated with a Ca2+-regulated myosin. 
  • Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. 
  • Engineered microsphere contrast agents for optical coherence tomography. 
  • Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. 
  • Enhanced optical imaging of human gliomas and tumor margins. 
  • Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients. 
  • Enhancing four-wave-mixing processes by nanowire arrays coupled to a gold film. 
  • Enhancing imaging systems using transformation optics. 
  • Estimation of macular pigment optical density in the elderly: test-retest variability and effect of optical blur in pseudophakic subjects. 
  • Facet-embedded thin-film III-V edge-emitting lasers integrated with SU-8 waveguides on silicon. 
  • Fast, high-resolution 3D dosimetry utilizing a novel optical-CT scanner incorporating tertiary telecentric collimation. 
  • Fast-Fourier-domain delay line for in vivo optical coherence tomography with a polygonal scanner. 
  • Femtomolar sensitivity using a channel-etched thin film waveguide fluoroimmunosensor. 
  • Femtosecond phase-coherent two-dimensional spectroscopy. 
  • Functional specificity of callosal connections in tree shrew striate cortex. 
  • Generalized sampling using a compound-eye imaging system for multi-dimensional object acquisition. 
  • Genetic engineering of a single-chain antibody fragment for surface immobilization in an optical biosensor. 
  • High-resolution cross-sectional imaging of the gastrointestinal tract using optical coherence tomography: preliminary results. 
  • High-resolution endoscopic imaging of the GI tract using optical coherence tomography. 
  • Hyperspectral imaging system using acousto-optic tunable filter for flow cytometry applications. 
  • Impact of epithelial basement membrane dystrophy and Salzmann nodular degeneration on biometry measurements. 
  • Implantable, multifunctional, bioresorbable optics. 
  • Implanted neural interfaces: biochallenges and engineered solutions. 
  • In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth. 
  • Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. 
  • Increased optical magnification from 2.5x to 4.3x with technical modification lowers the positive margin rate in open radical retropubic prostatectomy. 
  • Insect communication: Polarized light as a butterfly mating signal. 
  • Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia. 
  • Integrated optical attenuated total reflection spectrometry of aqueous superstrates using prism-coupled polymer waveguides. 
  • Integration of photonic and silver nanowire plasmonic waveguides. 
  • Interindividual variation in human visual performance. 
  • Intraoperative optical imaging of epileptiform and functional activity. 
  • Intravitreal tissue plasminogen activator for the treatment of central retinal vein occlusion. 
  • Introduction to grayscale calibration and related aspects of medical imaging grade liquid crystal displays. 
  • Iterative aperture mask design in phase space using a rank constraint. 
  • Lateral and axial measurement differences between spectral-domain optical coherence tomography systems. 
  • Light for Life: International Year of Light 2015. 
  • Mitochondrial and intrinsic optical signals imaged during hypoxia and spreading depression in rat hippocampal slices. 
  • Mixed semiconductor alloys for optical devices. 
  • Molecular contrast in optical coherence tomography by use of a pump-probe technique. 
  • Multiple-analyte fluoroimmunoassay using an integrated optical waveguide sensor. 
  • Multiscale gigapixel photography. 
  • Multiscale lens design. 
  • Nanoprobes and nanobiosensors for monitoring and imaging individual living cells. 
  • New equivalent keratometry reading calculation with a rotating Scheimpflug camera for intraocular lens power calculation after myopic corneal surgery. 
  • New real-time technique to measure the size distribution of water-insoluble aerosols. 
  • New technology for assessing microstructural components of tendons and ligaments. 
  • Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations. 
  • Observation of transparency of Erbium-doped silicon nitride in photonic crystal nanobeam cavities. 
  • One- and two-photon absorption of highly conjugated multiporphyrin systems in the two-photon Soret transition region. 
  • Optical coherence tomography: a new high-resolution imaging technology to study cardiac development in chick embryos. 
  • Optical detection of macromolecular heparin via selective coextraction into thin polymeric films. 
  • Optical hazards of intraocular lenses during vitreous surgery. 
  • Optical imaging of bipolar cortical stimulation. 
  • Optical nanobiosensor for monitoring an apoptotic signaling process in a single living cell following photodynamic therapy. 
  • Optical near-field mapping of plasmonic nanoprisms. 
  • Optical probes and techniques for molecular contrast enhancement in coherence imaging. 
  • Optical response of linear chains of metal nanospheres and nanospheroids. 
  • Optical sensor for the detection of caspase-9 activity in a single cell. 
  • Optical trapping near resonance absorption. 
  • Overview of functional imaging. 
  • Partially coherent illumination in full-field interferometric synthetic aperture microscopy. 
  • Pioneers in biomedical optics: special section honoring professor Frans F. Jobsis of Duke University. 
  • Planar integrated optical methods for examining thin films and their surface adlayers. 
  • Plasmonic Luneburg and Eaton lenses. 
  • Plasmonic nanoprobes for SERS biosensing and bioimaging. 
  • Plasmonic waveguide modes of film-coupled metallic nanocubes. 
  • Plastinated tissue samples as three-dimensional models for optical instrument characterization. 
  • Potentiometric, electronic structural, and ground- and excited-state optical properties of conjugated bis[(porphinato)zinc(II)] compounds featuring proquinoidal spacer units. 
  • Prospective multicenter study of toric IOL outcomes when dual zone automated keratometry is used for astigmatism planning. 
  • Quantification of the tip movement of lithotripsy flexible pneumatic probes. 
  • Radiation dosimetry using three-dimensional optical random access memories. 
  • Rapid pulse shaping with homodyne detection for measuring nonlinear optical signals 
  • Real-time in vivo color Doppler optical coherence tomography. 
  • Scanning fiber angle-resolved low coherence interferometry. 
  • Self-phase modulation signatures of neuronal activity 
  • Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip. 
  • Simultaneous self-phase modulation and two-photon absorption measurement by a spectral homodyne Z-scan method 
  • Simultaneous two-wavelength transmission quantitative phase microscopy with a color camera. 
  • Spectral analysis of induced color change on periodically nanopatterned silk films. 
  • Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials. 
  • The development of optical nanosensors for biological measurements. 
  • The motion of a single molecule, the lambda-receptor, in the bacterial outer membrane. 
  • The prospects for high resolution optical brain imaging: the magnetic resonance perspective. 
  • Theoretical strategy for choosing piggyback intraocular lens powers in young children. 
  • Thermal lens measurements in the cornea. 
  • Total internal reflection fluorescence microscopy (TIRFM). II. Topographical mapping of relative cell/substratum separation distances. 
  • Transformation-optical design of adaptive beam bends and beam expanders. 
  • Transport of superparamagnetic beads through a two-dimensional potential energy landscape. 
  • Ultrashort laser pulse bioeffects and safety. 
  • Video-rate compressive holographic microscopic tomography. 
  • Viewing angle performance of medical liquid crystal displays. 
  • Virtual electrode effects in transvenous defibrillation-modulation by structure and interface: evidence from bidomain simulations and optical mapping. 
  • Which media are most likely to solve the archival problem? 
  • Working strokes by single molecules of the kinesin-related microtubule motor ncd. 
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  Keywords of People

  • Brady, David J., Michael J. Fitzpatrick Distinguished Professor of Photonics in the Edmund T. Pratt, Jr. School of Engineering, Electrical and Computer Engineering
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Gehm, Michael E., Associate Professor of Electrical and Computer Engineering, Electrical and Computer Engineering
  • Horstmeyer, Roarke, Assistant Professor of Biomedical Engineering, Electrical and Computer Engineering
  • Jokerst, Nan Marie, J. A. Jones Distinguished Professor of Electrical and Computer Engineering, Duke University Energy Initiative
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering
  • Virgin, Lawrence N., Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science
  • Yellen, Benjamin, Associate Professor in the Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science