X-Ray Microtomography

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  Subject Areas on Research

  • 4D micro-CT for cardiac and perfusion applications with view under sampling. 
  • A collection of non-human primate computed tomography scans housed in MorphoSource, a repository for 3D data. 
  • A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer. 
  • A digital collection of rare and endangered lemurs and other primates from the Duke Lemur Center. 
  • Acoustic particle motion detection in the snapping shrimp (Alpheus richardsoni). 
  • Advances in micro-CT imaging of small animals. 
  • Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice. 
  • Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. 
  • Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. 
  • Astragalar morphology of Afradapis, a large adapiform primate from the earliest late Eocene of Egypt. 
  • Bone Marrow Stress Decreases Osteogenic Progenitors. 
  • Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss. 
  • Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial. 
  • Changes in orientation of attritional wear facets with implications for jaw motion in a mixed longitudinal sample of Propithecus edwardsi from Ranomafana National Park, Madagascar. 
  • Characterization of a composite injury model of severe lower limb bone and nerve trauma. 
  • Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors. 
  • Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. 
  • Comparative skeletal anatomy of neonatal ursids and the extreme altriciality of the giant panda. 
  • Comparing Dirichlet normal surface energy of tooth crowns, a new technique of molar shape quantification for dietary inference, with previous methods in isolation and in combination. 
  • Comparison of 4D-microSPECT and microCT for murine cardiac function. 
  • Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography. 
  • Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency. 
  • Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. 
  • Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning. 
  • Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD). 
  • Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. 
  • Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees. 
  • Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK? 
  • Dual source hybrid spectral micro-CT using an energy-integrating and a photon-counting detector. 
  • Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. 
  • Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas. 
  • Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss. 
  • Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration. 
  • Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone. 
  • Functional imaging of tumor vasculature using iodine and gadolinium-based nanoparticle contrast agents: a comparison of spectral micro-CT using energy integrating and photon counting detectors. 
  • G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. 
  • Gearing for speed slows the predatory strike of a mantis shrimp. 
  • Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification. 
  • Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice. 
  • Imaging primary lung cancers in mice to study radiation biology. 
  • Impaction durability of porous polyether-ether-ketone (PEEK) and titanium-coated PEEK interbody fusion devices. 
  • In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. 
  • In vivo small-animal imaging using micro-CT and digital subtraction angiography. 
  • Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice. 
  • Internal carotid arterial canal size and scaling in Euarchonta: Re-assessing implications for arterial patency and phylogenetic relationships in early fossil primates. 
  • Internal strain gradients quantified in bone under load using high-energy X-ray scattering. 
  • Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee. 
  • Local deformation behavior of surface porous polyether-ether-ketone. 
  • Low-dose 4D cardiac imaging in small animals using dual source micro-CT. 
  • Lower molar shape and size in prosimian and platyrrhine primates. 
  • Lowering circulating apolipoprotein E levels improves aged bone fracture healing. 
  • Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats. 
  • Micro-CT of rodents: state-of-the-art and future perspectives. 
  • Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease. 
  • Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging. 
  • Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells. 
  • Molecular Mass-Dependent Resorption and Bone Regeneration of 3D Printed PPF Scaffolds in a Critical-Sized Rat Cranial Defect Model. 
  • Oldest known cranium of a juvenile New World monkey (Early Miocene, Patagonia, Argentina): implications for the taxonomy and the molar eruption pattern of early platyrrhines. 
  • Patterns of astragalar fibular facet orientation in extant and fossil primates and their evolutionary implications. 
  • Pediatric Coronal Suture Fiber Alignment and the Effect of Interdigitation on Coronal Suture Mechanical Properties. 
  • Photon Counting CT and Radiomic Analysis Enables Differentiation of Tumors Based on Lymphocyte Burden. 
  • Photon-counting cine-cardiac CT in the mouse. 
  • Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis. 
  • Pullout strength of suture anchors: effect of mechanical properties of trabecular bone. 
  • Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization. 
  • Remobilization of residual non-aqueous phase liquid in porous media by freeze-thaw cycles. 
  • Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. 
  • Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography. 
  • Ritualized fighting and biological armor: the impact mechanics of the mantis shrimp's telson. 
  • Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis. 
  • Shark centra microanatomy and mineral density variation studied with laboratory microComputed Tomography. 
  • Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis. 
  • Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. 
  • Temporal and spectral imaging with micro-CT. 
  • The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. 
  • The effect of the trabecular microstructure on the pullout strength of suture anchors. 
  • The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging. 
  • Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture. 
  • Three-dimensional reconstruction in free-space whole-body fluorescence tomography of mice using optically reconstructed surface and atlas anatomy. 
  • Trabecular evidence for a human-like gait in Australopithecus africanus. 
  • Variations of stress field and stone fracture produced at different lateral locations in a shockwave lithotripter field. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering