Retinal Pigment Epithelium
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Subject Areas on Research
- (Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling.
- A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).
- A Case of Progressive Dimming Vision.
- A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration.
- A2E Distribution in RPE Granules in Human Eyes.
- Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.
- All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death.
- Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration.
- Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium.
- Anti-Vascular Endothelial Growth Factor Use and Atrophy in Neovascular Age-Related Macular Degeneration: Systematic Literature Review and Expert Opinion.
- Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.
- Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.
- Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways.
- Autofluorescence of choroidal nevus in 64 cases.
- Automated Recognition of Retinal Pigment Epithelium Cells on Limited Training Samples Using Neural Networks.
- Blue Light Fundus Autofluorescence in Coats Disease.
- Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration.
- CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish.
- COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS.
- Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration.
- Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies.
- Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies.
- Choroid plexus in the eye: a case study.
- Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration.
- Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography.
- Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.
- Complement-mediated release of fibroblast growth factor 2 from human RPE cells.
- Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT: Classification of Atrophy Report 3.
- Controlled exosome release from the retinal pigment epithelium in situ.
- DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
- Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial.
- Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers.
- Distribution of OCT Features within Areas of Macular Atrophy or Scar after 2 Years of Anti-VEGF Treatment for Neovascular AMD in CATT.
- Does senescence play a role in age-related macular degeneration?
- Drusen Volume and Retinal Pigment Epithelium Abnormal Thinning Volume Predict 2-Year Progression of Age-Related Macular Degeneration.
- Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference.
- Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.
- Early signs of exudative age-related macular degeneration in Asians.
- Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.
- Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus.
- Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs.
- Estrogen receptor beta protects against in vivo injury in RPE cells.
- Expanding the clinical phenotype in patients with disease causing variants associated with atypical Usher syndrome.
- Expression and modulation of RPE cell membrane complement regulatory proteins.
- Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.
- Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.
- Fully automatic software for retinal thickness in eyes with diabetic macular edema from images acquired by cirrus and spectralis systems.
- Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis.
- Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration.
- Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.
- Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
- High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.
- Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice.
- Imaging Features Associated with Progression to Geographic Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 5.
- Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings.
- Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss.
- In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques.
- Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial.
- Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4.
- Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration.
- Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.
- Isolation of Retinal Exosome Biomarkers from Blood by Targeted Immunocapture.
- LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.
- Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT.
- Long-term Evolution and Remodeling of Soft Drusen in Rhesus Macaques.
- Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.
- MULTIMODAL ASSESSMENTS OF DRUSENOID PIGMENT EPITHELIAL DETACHMENTS IN THE AGE-RELATED EYE DISEASE STUDY 2 ANCILLARY SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY COHORT.
- Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography.
- Macular Morphology and Visual Acuity in the Second Year of the Comparison of Age-Related Macular Degeneration Treatments Trials.
- Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.
- Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology.
- NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes.
- Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17.
- Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study).
- Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.
- New Insights Into Pentosan Polysulfate Maculopathy.
- Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study.
- Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration.
- Nuclear receptors as potential therapeutic targets for age-related macular degeneration.
- Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration.
- Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration.
- Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development.
- Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.
- PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE.
- PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration.
- PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration.
- Peripheral Retinal Changes Associated with Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group.
- Physical exosome:exosome interactions.
- Polarized Exosome Release from the Retinal Pigmented Epithelium.
- Potential therapeutic targets for age-related macular degeneration: The nuclear option.
- Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation.
- Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.
- Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.
- Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells.
- Quantification of Change in Pigment Epithelial Detachment Volume and Morphology After Transition to Intravitreal Aflibercept in Eyes With Recalcitrant Neovascular AMD: 18-Month Results.
- Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging.
- Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen.
- Quantitative classification of eyes with and without intermediate age-related macular degeneration using optical coherence tomography.
- Re: Pachychoroid neovasculopathy.
- Re: Spaide et al.: Volume-rendering optical coherence tomography angiography of macular telangiectasia type 2 (Ophthalmology 2015;122:2261-9).
- Recurrent choroidal neovascularization after macular translocation surgery with 360-degree peripheral retinectomy.
- Regulation of age-related macular degeneration-like pathology by complement factor H.
- Regulation of angiotensin II receptors and extracellular matrix turnover in human retinal pigment epithelium: role of angiotensin II.
- Relating Retinal Morphology and Function in Aging and Early to Intermediate Age-related Macular Degeneration Subjects.
- Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration.
- Resolution of persistent pigment epithelial detachment secondary to polypoidal choroidal vasculopathy in response to Aflibercept.
- Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells.
- Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress.
- Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.
- Retinal pigment epithelial detachments in age-related macular degeneration: classification and therapeutic options.
- Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration.
- Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning-Enabled Outer Retinal Feature Extraction.
- Risuteganib Protects against Hydroquinone-induced Injury in Human RPE Cells.
- Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
- Single-camera sequential-scan-based polarization-sensitive SDOCT for retinal imaging.
- Spectral domain optical coherence tomography imaging of geographic atrophy margins.
- Spectral-Domain OCT Analysis of Risk Factors for Macular Atrophy Development in the HARBOR Study for Neovascular Age-Related Macular Degeneration.
- Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro.
- Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.
- Subretinal Mononuclear Cells in Coats' Disease Studied with RPE65 and CD163: Evidence for Histiocytoid Pigment Epithelial Cells.
- T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.
- The hydrolytic susceptibility of prochelator BSIH in aqueous solutions.
- The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.
- The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.
- The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.
- The relationship between pigment epithelial detachment and visual outcome in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
- The role of Bcl-xL in mouse RPE cell survival.
- Update on maculopathy secondary to pentosan polysulfate toxicity.
- Validated automatic segmentation of AMD pathology including drusen and geographic atrophy in SD-OCT images.
- Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations.
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Keywords of People
- Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
- Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
- Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
- Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering