AMP-Activated Protein Kinases
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Subject Areas on Research
- A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
- A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.
- A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.
- AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.
- AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells.
- AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
- AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia.
- Akt-dependent and -independent mechanisms of mTOR regulation in cancer.
- Alglucosidase alfa enzyme replacement therapy as a therapeutic approach for a patient presenting with a PRKAG2 mutation.
- Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.
- Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer.
- Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells.
- Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.
- Characterization of the CaMKKβ-AMPK signaling complex.
- Chutes and Ladders: the search for protein kinases that act on AMPK.
- Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.
- Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
- Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
- Diet and sex modify exercise and cardiac adaptation in the mouse.
- Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.
- Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines.
- Effects of chemically induced ovarian failure on voluntary wheel-running exercise and cardiac adaptation in mice.
- Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.
- Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans.
- G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.
- Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
- Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.
- Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.
- Glycogen storage diseases presenting as hypertrophic cardiomyopathy.
- Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
- Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.
- KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
- LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.
- LKB1 reduces ROS-mediated cell damage via activation of p38.
- Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids.
- Lipids at the interface of virus-host interactions.
- Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.
- Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
- Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK.
- Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
- Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
- Obesity and altered angiogenic-related gene expression in endometrial cancer.
- PRKAG2 mutations presenting in infancy.
- Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells.
- Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.
- Rare coding variants and X-linked loci associated with age at menarche.
- Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.
- Role of transcription factor NFAT in glucose and insulin homeostasis.
- STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.
- Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.
- Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer.
- Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.
- Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.
- The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.
- The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
- The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse.
- The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading.
- The tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but-3-en-1-yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways in BV-2 microglia.
- Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.
- Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.
- Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.
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Keywords of People
- Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology