AMP-Activated Protein Kinases

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  Subject Areas on Research

  • A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration. 
  • A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. 
  • A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. 
  • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. 
  • AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells. 
  • AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. 
  • AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia. 
  • Akt-dependent and -independent mechanisms of mTOR regulation in cancer. 
  • Alglucosidase alfa enzyme replacement therapy as a therapeutic approach for a patient presenting with a PRKAG2 mutation. 
  • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. 
  • Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. 
  • Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells. 
  • Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. 
  • Characterization of the CaMKKβ-AMPK signaling complex. 
  • Chutes and Ladders: the search for protein kinases that act on AMPK. 
  • Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. 
  • Diet and sex modify exercise and cardiac adaptation in the mouse. 
  • Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. 
  • Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. 
  • Effects of chemically induced ovarian failure on voluntary wheel-running exercise and cardiac adaptation in mice. 
  • Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. 
  • Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans. 
  • G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. 
  • Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population. 
  • Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk. 
  • Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. 
  • Glycogen storage diseases presenting as hypertrophic cardiomyopathy. 
  • Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. 
  • Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. 
  • KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. 
  • LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells. 
  • LKB1 reduces ROS-mediated cell damage via activation of p38. 
  • Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids. 
  • Lipids at the interface of virus-host interactions. 
  • Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. 
  • Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • Obesity and altered angiogenic-related gene expression in endometrial cancer. 
  • PRKAG2 mutations presenting in infancy. 
  • Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. 
  • Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. 
  • Rare coding variants and X-linked loci associated with age at menarche. 
  • Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. 
  • Role of transcription factor NFAT in glucose and insulin homeostasis. 
  • STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment. 
  • Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape. 
  • Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer. 
  • Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells. 
  • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. 
  • The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. 
  • The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading. 
  • The tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but-3-en-1-yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways in BV-2 microglia. 
  • Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. 
  • Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. 
  • Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma. 
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  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology