Bone Morphogenetic Protein 2

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  Subject Areas on Research

  • A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 
  • A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • Adam10 is essential for early embryonic cardiovascular development. 
  • An injectable method for noninvasive spine fusion. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation. 
  • BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. 
  • BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • Bone formation induced by BMP-2 in human osteosarcoma cells. 
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. 
  • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. 
  • Bone morphogenetic proteins are expressed by both bone-forming and non-bone-forming lesions. 
  • Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. 
  • Cell-based gene therapy for repair of critical size defects in the rat fibula. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. 
  • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. 
  • Cost-Utility Analysis of rhBMP-2 Use in Adult Spinal Deformity Surgery. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Degenerative lumbar scoliosis. 
  • Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography. 
  • Does recombinant human bone morphogenetic protein-2 use in adult spinal deformity increase complications and are complications associated with location of rhBMP-2 use? A prospective, multicenter study of 279 consecutive patients. 
  • Editorial: Recombinant human bone morphogenetic protein-2. 
  • Encapsulation of Adenovirus BMP2-Transduced Cells with PEGDA Hydrogels Allows Bone Formation in the Presence of Immune Response. 
  • Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies. 
  • Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. 
  • Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. 
  • Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism. 
  • Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification. 
  • Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment. 
  • In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts. 
  • Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Long-Segment Fusion for Adult Spinal Deformity Correction Using Low-Dose Recombinant Human Bone Morphogenetic Protein-2: A Retrospective Review of Fusion Rates. 
  • Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. 
  • Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. 
  • Outcomes of Bone Grafting of Bone Cysts After Total Ankle Arthroplasty. 
  • Outcomes of bone morphogenetic protein-2 in mature adults: posterolateral non-instrument-assisted lumbar decompression and fusion. 
  • Predictors of Revision Surgical Procedure Excluding Wound Complications in Adult Spinal Deformity and Impact on Patient-Reported Outcomes and Satisfaction: A Two-Year Follow-up. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres. 
  • Recombinant human bone morphogenetic protein-2 as an adjunct for spine fusion in a pediatric population. 
  • Restriction of hepatic competence by Fgf signaling. 
  • Safety, efficacy, and dosing of recombinant human bone morphogenetic protein-2 for posterior cervical and cervicothoracic instrumented fusion with a minimum 2-year follow-up. 
  • Scaffold-based rhBMP-2 therapy in a rat alveolar defect model: implications for human gingivoperiosteoplasty. 
  • Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. 
  • Sustained release of BMP-2 in a lipid-based microtube vehicle. 
  • Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients. 
  • TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. 
  • The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The use of allograft and recombinant human bone morphogenetic protein for instrumented atlantoaxial fusions. 
  • Valency-dependent affinity of bioactive hydroxyapatite-binding dendrons. 
  • [BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit]. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology