Bone Morphogenetic Protein 4

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  Subject Areas on Research

  • A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 
  • A comparative transcriptomic analysis of astrocytes differentiation from human neural progenitor cells. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • An essential role of Bmp4 in the atrioventricular septation of the mouse heart. 
  • BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bone Morphogenetic Proteins Are Expressed by Both Bone-Forming and Non-Bone-Forming Lesions. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway. 
  • Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. 
  • Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. 
  • Bone morphogenetic proteins in development. 
  • Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas. 
  • Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas. 
  • Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. 
  • Developmental biology: decisions, decisions! 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Early onset preeclampsia in a model for human placental trophoblast. 
  • Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. 
  • Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. 
  • Fgf8 is required for anterior heart field development. 
  • Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. 
  • Generation of articular chondrocytes from human pluripotent stem cells. 
  • Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • ITGA1 is upregulated in response to oxygen over time in a BMP4 model of trophoblast. 
  • Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. 
  • Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer. 
  • Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice. 
  • Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation. 
  • Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice. 
  • Regeneration of fat cells from myofibroblasts during wound healing. 
  • Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. 
  • Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. 
  • Specification of chondrocytes and cartilage tissues from embryonic stem cells. 
  • Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. 
  • The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. 
  • The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. 
  • Tissue interactions pattern the mesenchyme of the embryonic mouse lung. 
  • Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development. 
  • UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology