Metabolome

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  Subject Areas on Research

  • A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. 
  • A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates. 
  • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. 
  • A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism. 
  • A joint analysis of metabolomics and genetics of breast cancer. 
  • A longitudinal big data approach for precision health. 
  • A metabolic signature of colon cancer initiating cells. 
  • A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. 
  • A randomized intervention study to evaluate the effect of calcitriol therapy on the renin-angiotensin system in diabetes. 
  • Across-vendor standardization of semi-LASER for single-voxel MRS at 3T. 
  • Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism. 
  • Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations. 
  • Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. 
  • Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. 
  • Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. 
  • Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. 
  • Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort. 
  • Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes. 
  • Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. 
  • Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. 
  • Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. 
  • Causal Genetic Variation Underlying Metabolome Differences. 
  • Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile. 
  • Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy. 
  • Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer's Disease. 
  • Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans. 
  • Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations. 
  • Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease. 
  • Customized Consensus Spectral Library Building for Untargeted Quantitative Metabolomics Analysis with Data Independent Acquisition Mass Spectrometry and MetaboDIA Workflow. 
  • Differential volatile signatures from skin, naevi and melanoma: a novel approach to detect a pathological process. 
  • Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure. 
  • Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study. 
  • ER stress modulates cellular metabolism. 
  • Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization. 
  • Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. 
  • Enabling high-throughput biology with flexible open-source automation. 
  • Endothelial dysfunction and cardiovascular disease in childhood obesity. 
  • Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach. 
  • Estimating relative changes of metabolic fluxes. 
  • Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy. 
  • Extending breath analysis to the cellular level: current thoughts on the human microbiome and the expression of organic compounds in the human exposome. 
  • Extraction parameters for metabolomics from cultured cells. 
  • Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. 
  • Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants. 
  • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. 
  • Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. 
  • Global metabolic profiling of human osteoarthritic synovium. 
  • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. 
  • Gut microbiota from twins discordant for obesity modulate metabolism in mice. 
  • HIF1α and HIF2α exert distinct nutrient preferences in renal cells. 
  • HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. 
  • Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages. 
  • High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. 
  • High-resolution metabolic mapping of cell types in plant roots. 
  • In-Depth Characterization and Validation of Human Urine Metabolomes Reveal Novel Metabolic Signatures of Lower Urinary Tract Symptoms. 
  • Increasing atmospheric CO2 reduces metabolic and physiological differences between isoprene- and non-isoprene-emitting poplars. 
  • Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature. 
  • Inflammatory cytokines and cellular metabolites as synovial fluid biomarkers of posttraumatic ankle arthritis. 
  • International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis. 
  • Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis. 
  • Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. 
  • Investigating the Role of Class I Adenylate-Forming Enzymes in Natural Product Biosynthesis. 
  • Ion mobility derived collision cross sections to support metabolomics applications. 
  • Leptin therapy in insulin-deficient type I diabetes. 
  • Leveraging leptin for type I diabetes? 
  • Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation. 
  • Maternal BMI and Glycemia Impact the Fetal Metabolome. 
  • Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism. 
  • Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries. 
  • Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. 
  • Metabolic Teamwork in the Stem Cell Niche. 
  • Metabolic interactions with cancer epigenetics. 
  • Metabolic profiles of second-generation antipsychotics in early psychosis: findings from the CAFE study. 
  • Metabolic profiles, energy expenditures, and body compositions of the weight regain versus sustained weight loss patients who underwent Roux-en-Y gastric bypass. 
  • Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. 
  • Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study. 
  • Metabolome-based signature of disease pathology in MS. 
  • Metabolomic Signature as a Predictor of Liver Disease Events in Patients With HIV/HCV Coinfection. 
  • Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. 
  • Metabolomic analysis of insulin resistance across different mouse strains and diets. 
  • Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. 
  • Metabolomic effects of androgen deprivation therapy treatment for prostate cancer. 
  • Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. 
  • Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. 
  • Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients. 
  • Metabolomics and Metabolic Diseases: Where Do We Stand? 
  • Metabolomics applied to diabetes research: moving from information to knowledge. 
  • Metabolomics in nutrition research: biomarkers predicting mortality in children with severe acute malnutrition. 
  • Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. 
  • Metabolomics, pathway regulation, and pathway discovery. 
  • Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers. 
  • MiMeDB: the Human Microbial Metabolome Database. 
  • MiR-106a-5p modulates apoptosis and metabonomics changes by TGF-β/Smad signaling pathway in cleft palate. 
  • Molecular biomarkers in glaucoma. 
  • Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. 
  • Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction. 
  • Obese humans with nonalcoholic fatty liver disease display alterations in fecal microbiota and volatile organic compounds. 
  • Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. 
  • Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects. 
  • Pharmacometabolomics reveals racial differences in response to atenolol treatment. 
  • Phenotypic mapping of metabolic profiles using self-organizing maps of high-dimensional mass spectrometry data. 
  • Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure. 
  • Plasma Metabolites and Risk of Radiation-induced Esophagitis: A Secondary Analysis from a Prospective Study. 
  • Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles. 
  • Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. 
  • Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease. 
  • Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. 
  • Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. 
  • Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. 
  • Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. 
  • Reprioritization of biofilm metabolism is associated with nutrient adaptation and long-term survival of Haemophilus influenzae. 
  • Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. 
  • Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome. 
  • Sex and race differences of cerebrospinal fluid metabolites in healthy individuals. 
  • Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis. 
  • Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells. 
  • Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance. 
  • Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow. 
  • Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. 
  • The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. 
  • The critical role of dietary foliage in maintaining the gut microbiome and metabolome of folivorous sifakas. 
  • The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. 
  • The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback. 
  • The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia. 
  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. 
  • Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma. 
  • Untargeted metabolomics analysis of ischemia-reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats. 
  • Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study. 
  • Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Reker, Daniel, Assistant Professor of Biomedical Engineering, Biomedical Engineering
  • Yancy Jr., William Samuel, Professor of Medicine, Medicine, General Internal Medicine