Neurogenesis

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  Subject Areas on Research

  • A comparative transcriptomic analysis of astrocytes differentiation from human neural progenitor cells. 
  • A human pluripotent stem cell platform for assessing developmental neural toxicity screening. 
  • Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. 
  • Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus. 
  • Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons. 
  • Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. 
  • Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. 
  • An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus. 
  • An early cell shape transition drives evolutionary expansion of the human forebrain. 
  • Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. 
  • Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis. 
  • Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position. 
  • Breaking bad blood: β2-microglobulin as a pro-aging factor in blood. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • C. elegans as a model to study glial development. 
  • CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. 
  • Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. 
  • Care for child development: basic science rationale and effects of interventions. 
  • Cell adhesion molecules regulating astrocyte-neuron interactions. 
  • Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation. 
  • Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil. 
  • Chemokines and the hippocampus: a new perspective on hippocampal plasticity and vulnerability. 
  • Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. 
  • Chordin is required for neural but not axial development in sea urchin embryos. 
  • Chromatin Regulation of Neuronal Maturation and Plasticity. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo. 
  • Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. 
  • Control of neural development and function by glial neuroligins. 
  • Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate. 
  • Developmental origin of peripheral ciliary band neurons in the sea urchin embryo. 
  • Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium. 
  • Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo. 
  • Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. 
  • Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems? 
  • Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. 
  • Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. 
  • Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. 
  • Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus. 
  • Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. 
  • Electroencephalography measures of relative power and coherence as reaching skill emerges in infants born preterm. 
  • Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation. 
  • Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus. 
  • Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution. 
  • Evolution: Does More Time Buy More Neurons? 
  • Expanding gliogenesis. 
  • Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction. 
  • Function of tau protein in adult newborn neurons. 
  • Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. 
  • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. 
  • GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons. 
  • Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. 
  • Generation and characterization of Tmeff2 mutant mice. 
  • Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression. 
  • Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions. 
  • Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways. 
  • Glucocorticoid hedgehog agonists in neurogenesis. 
  • Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. 
  • Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. 
  • HepaCAM controls astrocyte self-organization and coupling. 
  • Histone demethylases in neuronal differentiation, plasticity, and disease. 
  • Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins. 
  • Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. 
  • INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice. 
  • Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo. 
  • Immature excitatory neurons develop during adolescence in the human amygdala. 
  • Improving post-intensive care unit neuropsychiatric outcomes: understanding cognitive effects of physical activity. 
  • In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. 
  • In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. 
  • Injectable biomaterial shuttles for cell therapy in stroke. 
  • Integrative functional genomic analysis of human brain development and neuropsychiatric risks. 
  • Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors. 
  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. 
  • Molecular mechanisms of astrocyte-induced synaptogenesis. 
  • Morphological diversity of single neurons in molecularly defined cell types. 
  • Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex. 
  • Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma. 
  • Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels. 
  • Neural stem cell spacing questions their self-renewal. 
  • Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. 
  • Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus. 
  • Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation. 
  • Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. 
  • Nuclear phosphatase PPM1G in cellular survival and neural development. 
  • Nutrition and hearing loss: a neglected cause and global health burden. 
  • Origins and Proliferative States of Human Oligodendrocyte Precursor Cells. 
  • Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. 
  • Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development. 
  • Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. 
  • Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease. 
  • Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity. 
  • Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex. 
  • Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test. 
  • Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain. 
  • Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • Regeneration of cortical tissue from brain injury by implantation of defined molecular gradient of semaphorin 3A. 
  • Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming. 
  • Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans. 
  • Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum. 
  • Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. 
  • Retrograde neural circuit specification by target-derived neurotrophins and growth factors. 
  • Role of astrocytes in synapse formation and maturation. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells. 
  • Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. 
  • Sex-specific effects of adolescent intermittent ethanol exposure-induced dysregulation of hippocampal glial cells in adulthood. 
  • Silver impairs neurodevelopment: studies in PC12 cells. 
  • Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. 
  • Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. 
  • Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development. 
  • Synapsin III: role in neuronal plasticity and disease. 
  • The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features. 
  • The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The exon junction complex in neural development and neurodevelopmental disease. 
  • The immune system and developmental programming of brain and behavior. 
  • The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. 
  • The role of thrombin and protease-activated receptors in pain mechanisms. 
  • The title and data of Robinson and Madison (2016) are valid. 
  • Transcriptome and epigenome landscape of human cortical development modeled in organoids. 
  • Transcriptomic analysis of sea star development through metamorphosis to the highly derived pentameral body plan with a focus on neural transcription factors. 
  • Tripartite synaptomics: Cell-surface proximity labeling in vivo. 
  • Uncovering the HARbingers of human brain evolution. 
  • Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. 
  • Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation. 
  • Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease. 
  • Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood. 
  • Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology