snRNP Core Proteins

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  Subject Areas on Research

  • A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. 
  • Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. 
  • Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency. 
  • Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. 
  • Characterization and idiotypic analysis of an anti-RNP monoclonal antibody. 
  • Characterization of the human Snrpn minimal promoter and cis elements within it. 
  • Development of autoantibodies before the clinical onset of systemic lupus erythematosus. 
  • Expression of IgM and IgG autoantibodies in pediatric and adult systemic lupus erythematosus. 
  • Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. 
  • Hfq structure, function and ligand binding. 
  • Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression. 
  • Idiotypic cross-reaction between MRL autoantibodies and a BALB/c myeloma. 
  • Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity. 
  • IgG antinuclear antibodies with cross-reactive rheumatoid factor activity. 
  • Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice. 
  • Independent expression of autoantibodies in systemic lupus erythematosus. 
  • Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1. 
  • Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions. 
  • Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'. 
  • Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. 
  • Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE. 
  • Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies. 
  • Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. 
  • Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. 
  • Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. 
  • The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage. 
  • The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. 
  • The genetics of autoantibody production in MRL/lpr lupus mice. 
  • The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. 
  • The mouse Snrpn minimal promoter and its human orthologue: activity and imprinting. 
  • V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.