Biophysical Phenomena

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  Subject Areas on Research

  • A biophysical model for cardiac microimpedance measurements. 
  • A cone beam SPECT reconstruction algorithm with a displaced center of rotation. 
  • A fast dose calculation method based on table lookup for IMRT optimization. 
  • A filtered backprojection algorithm for axial head motion correction in fan-beam SPECT. 
  • A greedy heuristic using adjoint functions for the optimization of seed and needle configurations in prostate seed implant. 
  • A model for thermal ablation of biological tissue using laser radiation. 
  • A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels. 
  • A new model predicting locomotor cost from limb length via force production. 
  • A review of MR physics: 3T versus 1.5T. 
  • A space-time adaptive method for simulating complex cardiac dynamics. 
  • A tactile response in Staphylococcus aureus. 
  • A technique of automating compensator design for lung inhomogeneity correction using an electron portal imaging device. 
  • A vectorized Monte Carlo code for modeling photon transport in SPECT. 
  • Absence of a simple code: how transcription factors read the genome. 
  • Acceleration of dose calculations for intensity-modulated radiotherapy. 
  • An artificial neural network approach to quantitative single photon emission computed tomographic reconstruction with collimator, attenuation, and scatter compensation. 
  • An artificial neural network for estimating scatter exposures in portable chest radiography. 
  • An enthalpic model of anesthesia. 
  • Analysis of protein binding to receptor-doped lipid monolayers by Monte Carlo simulation. 
  • Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB. 
  • Approximate 3D iterative reconstruction for SPECT. 
  • Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. 
  • Automated computerized scheme for distinction between benign and malignant solitary pulmonary nodules on chest images. 
  • Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions. 
  • Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward. 
  • Binding of myosin subfragment 1 to glycerinated insect flight muscle in the rigor state. 
  • Bioelectrorheological model of the cell. 5. Electrodestruction of cellular membrane in alternating electric field. 
  • Biomembrane templates for nanoscale conduits and networks. 
  • Cell fission and formation of mini cell bodies by high frequency alternating electric field. 
  • Cell membrane deformation and bioeffects produced by tandem bubble-induced jetting flow. 
  • Clinical physics, applicator choice, technique, and equipment for electron intraoperative radiation therapy. 
  • Comparison of the IAEA TRS-398 and AAPM TG-51 absorbed dose to water protocols in the dosimetry of high-energy photon and electron beams. 
  • Compound scanning with a phased array. 
  • Computational motility models of neurogastroenterology and neuromodulation. 
  • Confocal imaging of intracellular chloride in living brain slices: measurement of GABAA receptor activity. 
  • Constructal law: pleasure, golden ratio, animal locomotion and the design of pedestrian evacuation: comment on "The emergence of design in pedestrian dynamics: locomotion, self-organization, walking paths and the constructal law" by A. Miguel. 
  • Contralateral subtraction: a novel technique for detection of asymmetric abnormalities on digital chest radiographs. 
  • Correlating the kinetics of cytokine-induced E-selectin adhesion and expression on endothelial cells. 
  • Deformation and flow of membrane into tethers extracted from neuronal growth cones. 
  • Designing an extracellular matrix protein with enhanced mechanical stability. 
  • Diffusion and mobility in a stirred dense granular material. 
  • Dismantling the Cryptococcus coat. 
  • Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. 
  • Donor-bridge-acceptor energetics determine the distance dependence of electron tunneling in DNA. 
  • Dynamic molecular processes mediate cellular mechanotransduction 
  • Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide. 
  • Effect of chain length and unsaturation on elasticity of lipid bilayers. 
  • Effect of contact time and force on monocyte adhesion to vascular endothelium. 
  • Elastic deformation and failure of lipid bilayer membranes containing cholesterol. 
  • Electromagnetic thermal therapy power optimization for multiple source applicators. 
  • Electrophysiological interaction through the interstitial space between adjacent unmyelinated parallel fibers. 
  • Engineering induction of singular neural rosette emergence within hPSC-derived tissues. 
  • Experimental comparison of noise and resolution for 2k and 4k storage phosphor radiography systems. 
  • Experimental spectral measurements of heavy K-edge filtered beams for x-ray computed mammotomography. 
  • Extracellular discontinuities in cardiac muscle: evidence for capillary effects on the action potential foot. 
  • Extracellular mass transport considerations for space flight research concerning suspended and adherent in vitro cell cultures. 
  • Factors regulating mammalian sperm migration through the female reproductive tract and oocyte vestments. 
  • Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions. 
  • Field Distribution of Transcranial Static Magnetic Stimulation in Realistic Human Head Model. 
  • Field-induced forces at dielectric interfaces as a possible mechanism of RF hearing effects. 
  • Finding the site of origin and velocity of propagation in a short one-dimensional strand from two extracellular waveforms. 
  • Firing-rate resonance in a generalized integrate-and-fire neuron with subthreshold resonance. 
  • Fluctuation-driven directional flow in biochemical cycle: further study of electric activation of Na,K pumps. 
  • Gating currents from a delayed rectifier K+ channel with altered pore structure and function. 
  • Getting Out of the Phosphate Bind: Trials to Guide Treatment Targets. 
  • H/D exchange and mass spectrometry-based method for biophysical analysis of multidomain proteins at the domain level. 
  • Hamster sperm penetration of the zona pellucida: kinematic analysis and mechanical implications. 
  • Heterogeneity and probabilistic binding contributions to receptor-mediated cell detachment kinetics. 
  • Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. 
  • Impact of resolution and noise characteristics of digital radiographic detectors on the detectability of lung nodules. 
  • In vivo visualization of abdominal malignancies with acoustic radiation force elastography. 
  • Integral dose conservation in radiotherapy. 
  • Intensity modulation optimization, lateral transport of radiation, and margins. 
  • Intensity-modulated radiotherapy by means of static tomotherapy: a planning and verification study. 
  • Is myosin a "back door" enzyme? 
  • Learning to control a brain-machine interface for reaching and grasping by primates. 
  • Letter to the Editor: on the electrocardiographic field equation. 
  • Liposome division by a simple bacterial division machinery. 
  • Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992. 
  • MECHANICS OF THE HUMAN FEMORAL ARTERY IN VIVO. 
  • Measurement of small mechanical vibrations of brain tissue exposed to extremely-low-frequency electric fields. 
  • Measurement of the presampling modulation transfer function of film digitizers using a curve fitting technique. 
  • Mechanism and specificity of lanthanide series cation transport by ionophores A23187, 4-BrA23187, and ionomycin. 
  • Membrane fusion promoters and inhibitors have contrasting effects on lipid bilayer structure and undulations. 
  • Membrane tethers formed from blood cells with available area and determination of their adhesion energy. 
  • Micropipette suction for measuring piconewton forces of adhesion and tether formation from neutrophil membranes. 
  • Modeling the effects of biologically incorporated radionuclides and chronic low-dose ionizing radiation exposure on both cancer and chronic non-cancer diseases. 
  • Modulation of activity and conduction in single dorsal column axons by kilohertz-frequency spinal cord stimulation. 
  • Morphology and mechanics of tongue movement in the African pig-nosed frog Hemisus marmoratum: a muscular hydrostatic model. 
  • Muscle force development after low-frequency magnetic burst stimulation in dogs. 
  • Myosin I contributes to the generation of resting cortical tension. 
  • Neuroprosthetic applications of electrical stimulation. 
  • Number and orientations of beams in intensity-modulated radiation treatments. 
  • Observed increase in local cooling effect of deforestation at higher latitudes. 
  • Optimization of a 90Sr/90Y radiation source train stepping for intravascular brachytherapy. 
  • Organization of skin stratum corneum extracellular lamellae: diffraction evidence for asymmetric distribution of cholesterol. 
  • Pain perception is altered by a nucleotide polymorphism in SCN9A. 
  • Phase diagram relationships in cryobiology. 
  • Phased array ultrasound imaging through planar tissue layers. 
  • Phosphorylation-dependent power output of transgenic flies: an integrated study. 
  • Physical principles governing the interrelationships of pressure, flow and volume in collapsible tubes. 
  • Pixel driven implementation of filtered backprojection for reconstruction of fan beam SPECT data using a position dependent effective projection bin length. 
  • Plate scatter correction for improved performance in dual-energy imaging. 
  • Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes. 
  • Prediction of heating patterns of a microwave interstitial antenna array at various insertion depths. 
  • Pressure-flow relationships in the ascending aorta and femoral artery of man. 
  • Principles of electrical stimulation of neural tissue. 
  • Probing the ethanol-induced chain interdigitations in gel-state bilayers of mixed-chain phosphatidylcholines. 
  • Protein structures in SDS micelle-protein complexes. 
  • Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation. 
  • Purification of kinesin-related protein complexes from eggs and embryos. 
  • Quantitative pulmonary single photon emission computed tomography for radiotherapy applications. 
  • RNA backbone is rotameric. 
  • Recent developments in biased agonism. 
  • Recognition and processing of randomly fluctuating electric signals by Na,K-ATPase. 
  • Reference dosimetry in clinical high-energy electron beams: comparison of the AAPM TG-51 and AAPM TG-21 dosimetry protocols. 
  • Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry. 
  • Schwan equation and transmembrane potential induced by alternating electric field. 
  • Segmentation of suspicious clustered microcalcifications in mammograms. 
  • Shock wave lithotripsy: the new phoenix? 
  • Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release. 
  • Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. 
  • Spectral coding in cat retinal ganglion cell receptive fields. 
  • Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction. 
  • Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy. 
  • Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. 
  • The 2004 Biophysical Society-Avanti Award in Lipids address: roles of bilayer structure and elastic properties in peptide localization in membranes. 
  • The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. 
  • The conformation of the active site of myosin probed using mant-nucleotides. 
  • The constructal law and the evolution of design in nature. 
  • The constructal law of organization in nature: tree-shaped flows and body size. 
  • The effect of gamma ray penetration on angle-dependent sensitivity for pinhole collimation in nuclear medicine. 
  • The hydration pressure between lipid bilayers. Comparison of measurements using x-ray diffraction and calorimetry. 
  • The impact of fluctuations in intensity patterns on the number of monitor units and the quality and accuracy of intensity modulated radiotherapy. 
  • The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz. 
  • The physics and neurobiology of magnetoreception. 
  • The relation between the torpor cycle and heat exchange in the California pocket mouse Perognathus californicus. 
  • The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The volar skin of primates: its frictional characteristics and their functional significance. 
  • Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. 
  • Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. 
  • Tunable molecular tension sensors reveal extension-based control of vinculin loading. 
  • Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution. 
  • Two-dimensional fluorescence intensity distribution analysis: theory and applications. 
  • Unifying constructal theory for scale effects in running, swimming and flying. 
  • Using patient data similarities to predict radiation pneumonitis via a self-organizing map. 
  • Validation of changes in extracellular volume measured during hemodialysis using a segmental bioimpedance technique. 
  • Viscosity of passive human neutrophils undergoing small deformations. 
  • Visual motion processing for the initiation of smooth-pursuit eye movements in humans. 
  • Vulnerability in an excitable medium: analytical and numerical studies of initiating unidirectional propagation. 
  • Wavelet formation in excitable cardiac tissue: the role of wavefront-obstacle interactions in initiating high-frequency fibrillatory-like arrhythmias. 
  • X-ray evidence that in contracting live frog muscles there exist two distinct populations of myosin heads. 
  • iRED analysis of TAR RNA reveals motional coupling, long-range correlations, and a dynamical hinge. 
  • pH-dependent conformational change of gastric mucin leads to sol-gel transition. 
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  Keywords of People

  • Craciunescu, Oana, Associate Professor of Radiation Oncology, Radiation Oncology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Henriquez, Craig S., Professor of Biomedical Engineering, Pratt School of Engineering
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science