Optical Phenomena

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  Subject Areas on Research

  • A highly distributed Bragg stack with unique geometry provides effective camouflage for Loliginid squid eyes. 
  • A low-cost, portable, and quantitative spectral imaging system for application to biological tissues. 
  • A method to correct for spectral artifacts in optical-CT dosimetry. 
  • A method to correct for stray light in telecentric optical-CT imaging of radiochromic dosimeters. 
  • Ablation of porcine ligamentum flavum with Ho:YAG, q-switched Ho:YAG, and quadrupled Nd:YAG lasers. 
  • Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium. 
  • Application of optical imaging and spectroscopy to radiation biology. 
  • Chip scale integrated microresonator sensing systems. 
  • Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption. 
  • Coherence revival multiplexed, buffered swept source optical coherence tomography: 400 kHz imaging with a 100 kHz source. 
  • Compact point-detection fluorescence spectroscopy system for quantifying intrinsic fluorescence redox ratio in brain cancer diagnostics. 
  • Control of the orientational order and nonlinear optical response of the "push-pull" chromophore RuPZn via specific incorporation into densely packed monolayer ensembles of an amphiphilic four-helix bundle peptide: characterization of the peptide-chromophore complexes. 
  • Cross-phase modulation imaging 
  • Detection of intestinal dysplasia using angle-resolved low coherence interferometry. 
  • Downwelling spectral irradiance during evening twilight as a function of the lunar phase. 
  • Dual-order snapshot spectral imaging of plasmonic nanoparticles. 
  • Encoded multichromophore response for simultaneous label-free detection. 
  • Fast voice-coil scanning optical-resolution photoacoustic microscopy. 
  • From active shape model to active optical flow model: a shape-based approach to predicting voxel-level dose distributions in spine SBRT. 
  • Functional photoacoustic microscopy of pH. 
  • Glassfrogs conceal blood in their liver to maintain transparency. 
  • Global chemical composition of ambient fine particulate matter for exposure assessment. 
  • High definition laparoscopy: objective assessment of performance characteristics and comparison with standard laparoscopy. 
  • High numerical aperture Fourier ptychography: principle, implementation and characterization. 
  • High responsivity, low dark current, heterogeneously integrated thin film Si photodetectors on rigid and flexible substrates. 
  • How to measure color using spectrometers and calibrated photographs. 
  • Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery. 
  • Identification of fluorescent beads using a coded aperture snapshot spectral imager. 
  • In vivo optical imaging of human vaginal gel thickness distributions with a probe-based, dual-modality instrument. 
  • In vivo optically encoded photoacoustic flowgraphy. 
  • In vivo photoacoustic microscopy with 7.6-µm axial resolution using a commercial 125-MHz ultrasonic transducer. 
  • Invited Review Article: Pump-probe microscopy 
  • Joint segmentation and reconstruction of hyperspectral data with compressed measurements. 
  • Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper 
  • Multiscale gigapixel photography. 
  • Nanoshells for photothermal cancer therapy. 
  • Near-infrared optical-resolution photoacoustic microscopy. 
  • Nonlinear phase dispersion spectroscopy. 
  • On the feasibility of optical-CT imaging in media of different refractive index. 
  • Optical Phase Measurements of Disorder Strength Link Microstructure to Cell Stiffness. 
  • Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth. 
  • Optical mapping of protein-DNA complexes on chromatin fibers. 
  • Optical performance comparison of deflectable laparoscopes for laparoendoscopic single-site surgery. 
  • Optical response of linear chains of metal nanospheres and nanospheroids. 
  • Photoacoustic microscopy of microvascular responses to cortical electrical stimulation. 
  • Polarization mapping of nanoparticle plasmonic coupling. 
  • Pump-probe imaging of historical pigments used in paintings 
  • Quantitative microscopy and nanoscopy of sickle red blood cells performed by wide field digital interferometry. 
  • Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models. 
  • Structured illumination diffraction phase microscopy for broadband, subdiffraction resolution, quantitative phase imaging 
  • The detection and role of molecular tension in focal adhesion dynamics. 
  • The digital flexible ureteroscope: in vitro assessment of optical characteristics. 
  • Visible light optical spectroscopy is sensitive to neovascularization in the dysplastic cervix. 
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  Keywords of People

  • Brady, David J., Michael J. Fitzpatrick Distinguished Professor Emeritus of Photonics, Electrical and Computer Engineering
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Gehm, Michael E., Professor of Electrical and Computer Engineering, Electrical and Computer Engineering
  • Hoffman, Brenton D., James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering, Biomedical Engineering
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering