Static Electricity

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  Subject Areas on Research

  • A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels. 
  • A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. 
  • A pseudobond parametrization for improved electrostatics in quantum mechanical/molecular mechanical simulations of enzymes. 
  • A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation. 
  • Adhesion between cerebroside bilayers. 
  • Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface. 
  • An empirical model for electrostatic interactions in proteins incorporating multiple geometry-dependent dielectric constants. 
  • Analytical Debye-Huckel model for electrostatic potentials around dissolved DNA. 
  • Applied electric fields accelerate the diffusion rate and increase the diffusion distance of DiI in fixed tissue. 
  • Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation. 
  • Assembly of alternating polycation and DNA multilayer films by electrostatic layer-by-layer adsorption. 
  • B-DNA to zip-DNA: simulating a DNA transition to a novel structure with enhanced charge-transport characteristics. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. 
  • Catalytic mechanism of 4-oxalocrotonate tautomerase: significances of protein-protein interactions on proton transfer pathways. 
  • Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults. 
  • Computational design of receptor and sensor proteins with novel functions. 
  • Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings. 
  • Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement. 
  • Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. 
  • Crystal structure of an activated response regulator bound to its target. 
  • Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation. 
  • DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA. 
  • Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer. 
  • Dynamic docking and electron-transfer between cytochrome b5 and a suite of myoglobin surface-charge mutants. Introduction of a functional-docking algorithm for protein-protein complexes. 
  • Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins. 
  • Electron ratcheting in self-assembled soft matter. 
  • Electrostatic Energetics of Bacillus subtilis Ribonuclease P Protein Determined by Nuclear Magnetic Resonance-Based Histidine pKa Measurements. 
  • Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+. 
  • Electrostatic control of phospholipid polymorphism. 
  • Essential role of conserved arginine 160 in intramolecular electron transfer in human sulfite oxidase. 
  • Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor. 
  • Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility. 
  • Evolution of graded refractive index in squid lenses. 
  • Fabrication of layer-by-layer deposited multilayer films containing DNA and its interaction with methyl green. 
  • Ferroelectric thin films in fluidic environments: a new interface for sensing and manipulation of matter. 
  • Flexible histone tails in a new mesoscopic oligonucleosome model. 
  • Free energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methods. 
  • Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. 
  • Hyperpolarized carbon-carbon intermolecular multiple quantum coherences. 
  • Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. 
  • Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap. 
  • Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. 
  • Leveraging nanoscale plasmonic modes to achieve reproducible enhancement of light. 
  • Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis. 
  • Liquid water simulations with the density fragment interaction approach. 
  • Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase. 
  • Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. 
  • Molecular interactions and residues involved in force generation in the T4 viral DNA packaging motor. 
  • Monte Carlo simulation and molecular theory of tethered polyelectrolytes. 
  • Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport. 
  • Multivariate analysis of attachment of biofouling organisms in response to material surface characteristics. 
  • NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. 
  • NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings. 
  • Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding. 
  • Organization of skin stratum corneum extracellular lamellae: diffraction evidence for asymmetric distribution of cholesterol. 
  • Origins of the helical wrapping of phenyleneethynylene polymers about single-walled carbon nanotubes. 
  • Ozone, Electrostatic Precipitators, and Particle Number Concentrations: Correlations Observed in a Real Office during Working Hours. 
  • Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells. 
  • Phosphatidylserine inhibits and calcium promotes model membrane fusion. 
  • Physical constraints on charge transport through bacterial nanowires. 
  • Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition. 
  • Predicting transition temperatures of elastin-like polypeptide fusion proteins. 
  • Probing Na(+)-induced changes in the HIV-1 TAR conformational dynamics using NMR residual dipolar couplings: new insights into the role of counterions and electrostatic interactions in adaptive recognition. 
  • Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. 
  • Quantum mechanics simulation of protein dynamics on long timescale. 
  • Quantum mechanics/molecular mechanics minimum free-energy path for accurate reaction energetics in solution and enzymes: sequential sampling and optimization on the potential of mean force surface. 
  • Reaction path potential for complex systems derived from combined ab initio quantum mechanical and molecular mechanical calculations. 
  • Role of nucleobase energetics and nucleobase interactions in single-stranded peptide nucleic acid charge transfer. 
  • Roles of bilayer material properties in function and distribution of membrane proteins. 
  • Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA. 
  • Sensing of molecules using quantum dynamics. 
  • Simulation of electron transfer between cytochrome C2 and the bacterial photosynthetic reaction center: Brownian dynamics analysis of the native proteins and double mutants. 
  • Size extensivity of the direct optimized effective potential method. 
  • Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. 
  • Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR. 
  • Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide. 
  • Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. 
  • Structural requirements for association of neurofascin with ankyrin. 
  • Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. 
  • Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. 
  • Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending. 
  • Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. 
  • Structure of the manganese-bound manganese transport regulator of Bacillus subtilis. 
  • Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy. 
  • Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery 
  • Synthesis of ring- and side-chain-substituted m-iodobenzylguanidine analogues. 
  • The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. 
  • The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. 
  • The compact conformation of fibronectin is determined by intramolecular ionic interactions. 
  • The hierarchical assembly of septins revealed by high-speed AFM. 
  • The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF 
  • Toward Building Protein Force Fields by Residue-Based Systematic Molecular Fragmentation and Neural Network. 
  • Tuning magnesium sensitivity of BK channels by mutations. 
  • Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. 
  • Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays. 
  • pH-dependent conformational change of gastric mucin leads to sol-gel transition. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology