Shc Signaling Adaptor Proteins
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Subject Areas on Research
- CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
- Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.
- Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts.
- Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans.
- Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
- Differential expression of receptor tyrosine kinases and Shc in fetal and adult rat fibroblasts: toward defining scarless versus scarring fibroblast phenotypes.
- G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
- G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
- Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
- Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
- Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy.
- Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
- Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.
- ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.
- The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.