Intervertebral Disc Degeneration

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  Subject Areas on Research

  • A magnetic resonance imaging framework for quantifying intervertebral disc deformation in vivo: Reliability and application to diurnal variations in lumbar disc shape. 
  • A prospective, multi-institutional comparative effectiveness study of lumbar spine surgery in morbidly obese patients: does minimally invasive transforaminal lumbar interbody fusion result in superior outcomes? 
  • An analysis from the Quality Outcomes Database, Part 2. Predictive model for return to work after elective surgery for lumbar degenerative disease. 
  • Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. 
  • Bone morphogenetic proteins and degenerative disk disease. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Cervical Disc Replacement: Are We There Yet? Commentary on an article by Michael E. Janssen, DO, et al.: "ProDisc-C Total Disc Replacement Versus Anterior Cervical Discectomy and Fusion for Single-Level Symptomatic Cervical Disc Disease. Seven-Year Follow-up of the Prospective Randomized U.S. Food and Drug Administration Investigational Device Exemption Study". 
  • Complications in adult spinal deformity surgery: an analysis of minimally invasive, hybrid, and open surgical techniques. 
  • Degenerative Spinal Deformity. 
  • Do measures of surgical effectiveness at 1 year after lumbar spine surgery accurately predict 2-year outcomes? 
  • Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice. 
  • Editorial: Recombinant human bone morphogenetic protein-2. 
  • Extreme lateral interbody fusion for the treatment of adult degenerative scoliosis. 
  • Frequency, risk factors, and treatment of distal adjacent segment pathology after long thoracolumbar fusion: a systematic review. 
  • Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients. 
  • Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. 
  • Impact of Dominant Symptom on 12-Month Patient-Reported Outcomes for Patients Undergoing Lumbar Spine Surgery. 
  • Impact of occupational characteristics on return to work for employed patients after elective lumbar spine surgery. 
  • In-Hospital Complications and Resource Utilization Following Lumbar Spine Surgery in Patients with Parkinson Disease: Evaluation of the National Inpatient Sample Database. 
  • Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project. 
  • Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells. 
  • Interpedicular height as a predictor of radicular pain in adult degenerative scoliosis. 
  • Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. 
  • Lumbar facet cyst resolution following anterior interbody fusion. 
  • Operative and nonoperative treatment approaches for lumbar degenerative disc disease have similar long-term clinical outcomes among patients with positive discography. 
  • Patient characteristics of smokers undergoing lumbar spine surgery: an analysis from the Quality Outcomes Database. 
  • Preoperative depression, lumbar fusion, and opioid use: an assessment of postoperative prescription, quality, and economic outcomes. 
  • Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. 
  • Randomized controlled trials for degenerative lumbar spondylolisthesis: which patients benefit from lumbar fusion? 
  • Refractory urgency urinary incontinence treatment in women: impact of age on outcomes and complications. 
  • Risk factors for 30-day reoperation and 3-month readmission: analysis from the Quality and Outcomes Database lumbar spine registry. 
  • Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial. 
  • Schmorl's nodes. 
  • Segmental contribution toward total lumbar range of motion in disc replacement and fusions: a comparison of operative and adjacent levels. 
  • TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. 
  • The Impact of Lumbar Spine Disease and Deformity on Total Hip Arthroplasty Outcomes. 
  • Total number and severity of comorbidities do not differ based on anatomical region of musculoskeletal pain.