Genetic Fitness

• 

  Subject Areas on Research

  • A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus). 
  • A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies. 
  • Antagonistic selection and pleiotropy constrain the evolution of plant chemical defenses. 
  • Can the Environment have a Genetic Basis? A Case Study of Seedling Establishment in Arabidopsis thaliana. 
  • Chimpanzee females queue but males compete for social status 
  • Costs of resistance and correlational selection in the multiple-herbivore community of Solanum carolinense. 
  • DNA copy number evolution in Drosophila cell lines. 
  • Evolutionary dynamics of tumor progression with random fitness values. 
  • Evolutionary genetics of plant adaptation. 
  • Genetic variance in fitness indicates rapid contemporary adaptive evolution in wild animals. 
  • Genome wide analyses reveal little evidence for adaptive evolution in many plant species. 
  • Geographical variation in postzygotic isolation and its genetic basis within and between two Mimulus species. 
  • How sticky should a virus be? The impact of virus binding and release on transmission fitness using influenza as an example. 
  • Hybridization can facilitate species invasions, even without enhancing local adaptation. 
  • Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome. 
  • Interploidal hybridization and mating patterns in the Sphagnum subsecundum complex. 
  • Is local adaptation in Mimulus guttatus caused by trade-offs at individual loci? 
  • Low demographic variability in wild primate populations: fitness impacts of variation, covariation, and serial correlation in vital rates. 
  • Molecular Biology and Evolution of Cancer: From Discovery to Action. 
  • Pervasive tertiary structure in the dengue virus RNA genome. 
  • Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death. 
  • PhyloOncology: Understanding cancer through phylogenetic analysis. 
  • Pioneering paradigms and magnificent manifestos--Leigh Van Valen's priceless contributions to evolutionary biology. 
  • Plasticity of plant defense and its evolutionary implications in wild populations of Boechera stricta. 
  • Pollinator-mediated selection on flower color allele drives reinforcement. 
  • Regulation of plant root system architecture: implications for crop advancement. 
  • Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus. 
  • Selective trade-offs maintain alleles underpinning complex trait variation in plants. 
  • Sex-specific fitness effects of unpredictable early life conditions are associated with DNA methylation in the avian glucocorticoid receptor. 
  • Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz. 
  • Social determinants of health and survival in humans and other animals. 
  • Sociality and health: impacts of sociality on disease susceptibility and transmission in animal and human societies. 
  • Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus. 
  • Strong selection genome-wide enhances fitness tradeoffs across environments and episodes of selection 
  • The Evolution of Sex is Tempered by Costly Hybridization in Boechera (Rock Cress). 
  • The cost of reinforcement: selection on flower color in allopatric populations of Phlox drummondii. 
  • The earliest stages of adaptation in an experimental plant population: strong selection on QTLs for seed dormancy. 
  • The effects of quantitative fecundity in the haploid stage on reproductive success and diploid fitness in the aquatic peat moss Sphagnum macrophyllum. 
  • The fitness benefits of germinating later than neighbors. 
  • The sociality-health-fitness nexus: synthesis, conclusions and future directions. 
  • The socio-genetics of a complex society: female gelada relatedness patterns mirror association patterns in a multilevel society. 
  • Threshold assessment, categorical perception, and the evolution of reliable signaling. 
  • Total Synthesis of a Functional Designer Eukaryotic Chromosome 
  • Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. 
  • Transcription-associated mutation of lasR in Pseudomonas aeruginosa. 
  • Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans. 
  • Unisexual reproduction reverses Muller's ratchet. 
  • Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. 
  • Variation and fitness costs for tolerance to different types of herbivore damage in Boechera stricta genotypes with contrasting glucosinolate structures. 
  • Why flying dogs are rare: A general theory of luck in evolutionary transitions. 
  • uORF-mediated translation allows engineered plant disease resistance without fitness costs. 
• 

  Keywords of People

  • Alberts, Susan C., Robert F. Durden Distinguished Professor of Biology, Duke Science & Society
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology