Histone Deacetylase 1
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Subject Areas on Research
- A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division.
- ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
- Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter.
- Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.
- Distinct in vivo requirements for establishment versus maintenance of transcriptional repression.
- Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia.
- Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication.
- Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
- Evaluation of class I HDAC isoform selectivity of largazole analogues.
- Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer.
- LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
- MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
- NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation.
- Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.
- Synthesis and biological evaluation of largazole zinc-binding group analogs.