Histone Deacetylase 1

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  Subject Areas on Research

  • A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 
  • Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. 
  • Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication. 
  • Evaluation of class I HDAC isoform selectivity of largazole analogues. 
  • Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. 
  • Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. 
  • Synthesis and biological evaluation of largazole zinc-binding group analogs.