Histone Deacetylase 1
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Subject Areas on Research
- ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
- Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter.
- Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.
- Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication.
- Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
- Evaluation of class I HDAC isoform selectivity of largazole analogues.
- LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
- MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
- Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.
- Synthesis and biological evaluation of largazole zinc-binding group analogs.