Histone Demethylases
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Subject Areas on Research
- A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity.
- Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.
- Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis.
- Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.
- Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors.
- Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.
- Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.
- Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.
- Failure of human rhombic lip differentiation underlies medulloblastoma formation.
- Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
- Histone demethylases in neuronal differentiation, plasticity, and disease.
- JMJD5 couples with CDK9 to release the paused RNA polymerase II.
- KDM1 class flavin-dependent protein lysine demethylases.
- KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.
- Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
- Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.
- Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.
- Opposing LSD1 complexes function in developmental gene activation and repression programmes.
- Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation.
- Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
- The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons.
- Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST.
- Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1.
- trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.