Sirtuin 1
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Subject Areas on Research
- A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2.
- AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia.
- Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
- Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells.
- Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.
- CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
- CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability.
- Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
- Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
- FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.
- Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
- Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells.
- Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
- Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
- Muscle oxidative capacity during IL-6-dependent cancer cachexia.
- Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
- Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.
- SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.
- SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
- Sirtuin-1 expression and activity is diminished in aged liver grafts.
- The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.
- Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway.