Sirtuin 1

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  Subject Areas on Research

  • A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2. 
  • CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. 
  • CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. 
  • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. 
  • Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. 
  • FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Muscle oxidative capacity during IL-6-dependent cancer cachexia. 
  • Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. 
  • The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway.