Sirtuin 3
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Subject Areas on Research
- Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
- Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.
- Disruption of the Ang II type 1 receptor promotes longevity in mice.
- Ethanol metabolism modifies hepatic protein acylation in mice.
- Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
- Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
- Mitochondrial protein acetylation regulates metabolism.
- Mitochondrial sirtuins.
- Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.
- Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.
- Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.
- Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.
- Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells.
- SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.
- SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.
- SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
- SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
- SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
- SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.
- SIRT3 regulates progression and development of diseases of aging.
- SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.
- Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.
- Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
- Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
- Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.
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Keywords of People
- Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology