Adaptive Immunity

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  Subject Areas on Research

  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. 
  • A rhesus macaque model of Asian-lineage Zika virus infection. 
  • A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. 
  • A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis. 
  • Actions of immune cells in the hypertensive kidney. 
  • Acute HIV-1 Infection. 
  • Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants. 
  • Adaptive immune response to therapy in hmgcr autoantibody myopathy. 
  • Adaptive immune responses to primary and secondary dengue virus infections. 
  • Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. 
  • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. 
  • Adjuvant effects of invariant NKT cell ligand potentiates the innate and adaptive immunity to an inactivated H1N1 swine influenza virus vaccine in pigs. 
  • Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. 
  • Ambient ozone and pulmonary innate immunity. 
  • Anti-tumor immunity: myeloid leukocytes control the immune landscape. 
  • Assessing and restoring adaptive immunity to HSV, VZV, and HHV-6 in solid organ and hematopoietic cell transplant recipients. 
  • Assessing the immune status of critically ill trauma patients by flow cytometry. 
  • B Cell-Adaptive Immune Profile in Emphysema-Predominant Chronic Obstructive Pulmonary Disease. 
  • B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. 
  • Biomaterial interactions with the immune system. 
  • C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking. 
  • CD1d, a sentinel molecule bridging innate and adaptive immunity, is downregulated by the human papillomavirus (HPV) E5 protein: a possible mechanism for immune evasion by HPV. 
  • CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques. 
  • Can Exercise-Induced Modulation of the Tumor Physiologic Microenvironment Improve Antitumor Immunity? 
  • Cellular changes in eculizumab early responders with generalized myasthenia gravis. 
  • Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies. 
  • Chemokines as adjuvants for immunotherapy: implications for immune activation with CCL3. 
  • Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma. 
  • Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation. 
  • Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. 
  • Complement system in lung transplantation. 
  • Computational investigations into the origins of short-term biochemical memory in T cell activation. 
  • Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. 
  • Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses. 
  • Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model. 
  • Developmental allometry and paediatric malaria. 
  • Does exercise attenuate age- and disease-associated dysfunction in unconventional T cells? Shining a light on overlooked cells in exercise immunology. 
  • Double agents in the war on cancer: leukocytes govern ovarian cancer progression. 
  • Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. 
  • Editorial: Viral Infection at the Maternal-Fetal Interface. 
  • Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth. 
  • Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells. 
  • Genes of innate immunity and the biological response to inhaled ozone. 
  • Genetics of childhood steroid-sensitive nephrotic syndrome. 
  • Harnessing virus tropism for dendritic cells for vaccine design. 
  • How and why do T cells and their derived cytokines affect the injured and healthy brain? 
  • Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection. 
  • Identification of early interactions between Francisella and the host. 
  • Immune mechanisms in inflammatory and degenerative eye disease. 
  • Immune pathogenesis of heparin-induced thrombocytopenia. 
  • Immune signatures predict prognosis in localized cancer. 
  • Immunology of vascularized composite allotransplantation: a primer for hand surgeons. 
  • Immunometabolism: From basic mechanisms to translation. 
  • Immunopathogenesis of genital Chlamydia infection: insights from mouse models. 
  • Immunosuppressive protocols and immunological challenges related to hand transplantation. 
  • Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models. 
  • In vivo downregulation of innate and adaptive immune responses in corneal allograft rejection by HC-HA/PTX3 complex purified from amniotic membrane. 
  • Infections in the immunosuppressed host. 
  • Influenza vaccines: mTOR inhibition surprisingly leads to protection. 
  • Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys. 
  • Innate and adaptive receptors interact to balance humoral immunity. 
  • Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant. 
  • Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study. 
  • Interactions of innate and adaptive immunity in brain development and function. 
  • Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. 
  • MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection. 
  • Mast cell activators as novel immune regulators. 
  • Mast cell-orchestrated immunity to pathogens. 
  • Mechanobiology likely contributes to immunobiology pathways in the pathogenesis of ankylosing spondyltitis. 
  • Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. 
  • Modulating adaptive immune responses to peptide self-assemblies. 
  • Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. 
  • Monocytes prime autoreactive T cells after myocardial infarction. 
  • New roles for mast cells in modulating allergic reactions and immunity against pathogens. 
  • New roles for mast cells in pathogen defense and allergic disease. 
  • Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. 
  • Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma. 
  • Osteopontin has a protective role in prostate tumor development in mice. 
  • Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. 
  • Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. 
  • Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion. 
  • Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. 
  • Programmed Cell Death in the Evolutionary Race against Bacterial Virulence Factors. 
  • Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1. 
  • Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections. 
  • Regulation of Viral Infection by the RNA Modification N6-Methyladenosine. 
  • RelB controls adaptive responses of astrocytes during sterile inflammation. 
  • Review: Collectins link innate and adaptive immunity in allergic airway disease. 
  • Salt, Hypertension, and Immunity. 
  • Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development. 
  • Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease. 
  • Supramolecular peptide vaccines: tuning adaptive immunity. 
  • Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes. 
  • Systems biology of vaccination for seasonal influenza in humans. 
  • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 
  • The Cutaneous Wound Innate Immunological Microenvironment. 
  • The cornea IV immunology, infection, neovascularization, and surgery chapter 1: Corneal immunology. 
  • The eye: A window to the soul of the immune system. 
  • The immunologic response to severe acute respiratory syndrome coronavirus 2. 
  • The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. 
  • The mast cell in innate and adaptive immunity. 
  • The nature of immune responses to urinary tract infections. 
  • The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice. 
  • The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques. 
  • This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts. 
  • Three-Year Durability of Immune Responses Induced by HIV-DNA and HIV-Modified Vaccinia Virus Ankara and Effect of a Late HIV-Modified Vaccinia Virus Ankara Boost in Tanzanian Volunteers. 
  • Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health. 
  • Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters. 
  • Using oncolytic viruses to ignite the tumour immune microenvironment in bladder cancer. 
  • Visualization of Immune Responses in the Cornea. 
  • Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis. 
  • Workshop on immunizations in older adults: identifying future research agendas. 
  • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. 
  • microRNAs at the regulatory frontier: an investigation into how microRNAs impact the development and effector functions of CD4 T cells. 
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  Keywords of People

  • Liao, Tzu-chieh, Student, Integrative Immunobiology
  • Pastva, Amy Martha, Professor in Orthopaedic Surgery, Cell Biology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology