Cyclin T

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  Subject Areas on Research

  • A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo. 
  • An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation. 
  • Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. 
  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. 
  • Canine cyclin T1 rescues equine infectious anemia virus tat trans-activation in human cells. 
  • Functional differences between human and bovine immunodeficiency virus Tat transcription factors. 
  • Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism. 
  • Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. 
  • Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat. 
  • Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.