Subject Areas on Research
- Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors.
- Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.
- Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway.
- NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.
- Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones.
- Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).
- The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
- The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo.
- The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.
- The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis.
- The thyroid axis is regulated by NCoR1 via its actions in the pituitary.
- The thyroid hormone receptor recruits NCoR via widely spaced receptor-interacting domains.
- The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
- Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
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