Induced Pluripotent Stem Cells
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Subject Areas on Research
- A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells.
- Accelerating stem cell trials for Alzheimer's disease.
- An early cell shape transition drives evolutionary expansion of the human forebrain.
- Apoptotic caspases regulate induction of iPSCs from human fibroblasts.
- CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues.
- Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.
- Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.
- Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs.
- Comparative analysis of media effects on human induced pluripotent stem cell-derived cardiomyocytes in proarrhythmia risk assessment.
- Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion.
- Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.
- Development and application of human skeletal muscle microphysiological systems.
- Differentiation of Human Induced Pluripotent Stem Cells into Epicardial-Like Cells.
- Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.
- Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
- EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome.
- Engineered skeletal muscles for disease modeling and drug discovery.
- Engineering human pluripotent stem cells into a functional skeletal muscle tissue.
- Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer's Disease.
- Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.
- Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs.
- Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.
- Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis.
- Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.
- Genome-wide chromatin state transitions associated with developmental and environmental cues.
- Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions.
- HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
- Harnessing developmental plasticity to pattern kidney organoids
- High-Efficiency Cellular Reprogramming by Nanoscale Puncturing.
- High-content imaging-based screening of microenvironment-induced changes to stem cells.
- High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays.
- Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.
- Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC-NPC Culture
- In Situ Fabrication and Perfusion of Tissue-Engineered Blood Vessel Microphysiological System.
- Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues.
- Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
- Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells.
- LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
- Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.
- Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
- MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics.
- Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species.
- MicroRNA delivery for regenerative medicine.
- Minireview: Nuclear receptors, hematopoiesis, and stem cells.
- Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities.
- Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
- Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.
- Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Hypothalamic Neurones Provides Developmental Insights into Genetic Loci for Body Weight Regulation.
- Multiplication of the SNCA locus exacerbates neuronal nuclear aging.
- Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators.
- Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons.
- Physically Associated Synthetic Hydrogels with Long-Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation
- Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function.
- Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.
- Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter.
- Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β.
- Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood.
- Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity.
- Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.
- Stem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts.
- Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.
- Synthetic transcription factors for cell fate reprogramming.
- The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.
- The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.
- Transcriptome and epigenome landscape of human cortical development modeled in organoids.
- Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair.
- WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs.
- iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
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Keywords of People
- Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering
- Landstrom, Andrew Paul, Associate Professor of Pediatrics, Cell Biology
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Pharmacology & Cancer Biology