Induced Pluripotent Stem Cells
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Subject Areas on Research
- A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells.
- A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells.
- Accelerating stem cell trials for Alzheimer's disease.
- Amniocytes can serve a dual function as a source of iPS cells and feeder layers.
- An Embryonic and Induced Pluripotent Stem Cell Model for Ovarian Granulosa Cell Development and Steroidogenesis.
- Apoptotic caspases regulate induction of iPSCs from human fibroblasts.
- CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues.
- Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.
- Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells.
- Comparative analysis of media effects on human induced pluripotent stem cell-derived cardiomyocytes in proarrhythmia risk assessment.
- Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion.
- Development and application of human skeletal muscle microphysiological systems.
- Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.
- Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells.
- Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro.
- Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.
- Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
- EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome.
- Engineering human pluripotent stem cells into a functional skeletal muscle tissue.
- Epigenetic therapy of Prader-Willi syndrome.
- Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.
- Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.
- Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis.
- Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.
- Genome-wide chromatin state transitions associated with developmental and environmental cues.
- HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
- High-content imaging-based screening of microenvironment-induced changes to stem cells.
- High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays.
- Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.
- Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture.
- Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues.
- Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
- Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells.
- LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
- Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.
- MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics.
- Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species.
- MicroRNA delivery for regenerative medicine.
- Minireview: Nuclear receptors, hematopoiesis, and stem cells.
- Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities.
- Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
- Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.
- Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Hypothalamic Neurones Provides Developmental Insights into Genetic Loci for Body Weight Regulation.
- Multiplication of the SNCA locus exacerbates neuronal nuclear aging.
- Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons.
- PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
- Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation.
- Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.
- Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.
- Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β.
- Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood.
- Reprogramming to pluripotency can conceal somatic cell chromosomal instability.
- Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.
- Stem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts.
- Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.
- Synthetic transcription factors for cell fate reprogramming.
- Transcriptome and epigenome landscape of human cortical development modeled in organoids.
- Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair.
- Universally Conserved Relationships between Nuclear Shape and Cytoplasmic Mechanical Properties in Human Stem Cells.
- WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs.
- iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
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Keywords of People
- Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering
- Landstrom, Andrew Paul, Assistant Professor of Pediatrics, Cell Biology
- McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship