Molecular Imaging

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  Subject Areas on Research

  • A hardware investigation of robotic SPECT for functional and molecular imaging onboard radiation therapy systems. 
  • A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs. 
  • A robust automated measure of average antibody staining in immunohistochemistry images. 
  • A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice. 
  • Application of optical imaging and spectroscopy to radiation biology. 
  • Associations between dopamine D2 receptor availability and BMI depend on age. 
  • Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair. 
  • Breast MRI radiogenomics: Current status and research implications. 
  • Cross-phase modulation imaging. 
  • Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography. 
  • Ex Vivo and In Vivo Noninvasive Imaging of Epidermal Growth Factor Receptor Inhibition on Colon Tumorigenesis Using Activatable Near-Infrared Fluorescent Probes. 
  • Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model. 
  • Femtosecond pulse shaping enables detection of optical Kerr-effect (OKE) dynamics for molecular imaging. 
  • Functional and molecular image guidance in radiotherapy treatment planning optimization. 
  • Future trends in lung cancer diagnosis. 
  • Hyperspectral molecular imaging of multiple receptors using immunolabeled plasmonic nanoparticles. 
  • Imaging molecular pathways: reporter genes. 
  • Imaging tumor hypoxia to advance radiation oncology. 
  • In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing. 
  • In vivo analysis of white adipose tissue in zebrafish. 
  • In vivo imaging and quantification of regional adiposity in zebrafish. 
  • In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters. 
  • In vivo photoacoustic tomography of myoglobin oxygen saturation. 
  • Initial neighborhood biases and the quality of motion stimulation jointly influence the rapid emergence of direction preference in visual cortex. 
  • Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. 
  • Introduction to the special issue on molecular imaging in radiation biology. 
  • Joint 2D and 3D phase processing for quantitative susceptibility mapping: application to 2D echo-planar imaging. 
  • Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. 
  • MRI properties of a unique hypo-intense layer in degraded articular cartilage. 
  • Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation. 
  • Molecular imaging for depressive disorders. 
  • Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes. 
  • Molecular imaging: T2-weighted CMR of the area at risk--a risky business? 
  • Molecular origin of a loading-induced black layer in the deep region of articular cartilage at the magic angle. 
  • Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission. 
  • Near-infrared-fluorescence-enhanced molecular imaging of live cells on gold substrates. 
  • Noninvasive imaging of peripheral nerves. 
  • Optical Phase Measurements of Disorder Strength Link Microstructure to Cell Stiffness. 
  • Optical imaging of tumor hypoxia dynamics. 
  • Photoacoustic microscopy of tyrosinase reporter gene in vivo. 
  • Prefrontal cortex output circuits guide reward seeking through divergent cue encoding. 
  • Pulsating tandem microbubble for localized and directional single-cell membrane poration. 
  • Pump-probe nonlinear phase dispersion spectroscopy. 
  • Quantitative phase imaging with molecular sensitivity using photoacoustic microscopy with a miniature ring transducer. 
  • Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel. 
  • Recent progress in photoacoustic molecular imaging. 
  • Recurrent circuitry dynamically shapes the activation of piriform cortex. 
  • Regeneration Genetics. 
  • Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping. 
  • Response to treatment series: part 1 and introduction, measuring tumor response--challenges in the era of molecular medicine. 
  • Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo. 
  • Snap-shot multispectral imaging of vascular dynamics in a mouse window-chamber model. 
  • Snapshot molecular imaging using coded energy-sensitive detection. 
  • Spatial frequency-domain multiplexed microscopy for simultaneous, single-camera, one-shot, fluorescent, and quantitative-phase imaging. 
  • Spectrally encoded confocal scanning laser ophthalmoscopy. 
  • Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. 
  • Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia. 
  • Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer. 
  • The effects of mechanical loading and gadolinium concentration on the change of T1 and quantification of glycosaminoglycans in articular cartilage by microscopic MRI. 
  • Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen. 
  • Toward the detection of cellular copper(II) by a light-activated fluorescence increase. 
  • Zebrafish assays of ciliopathies. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Fischer, Martin, Associate Research Professor in the Department of Chemistry, Chemistry
  • Johnson, G. Allan, Charles E. Putman University Professor of Radiology, Physics
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Patz Jr., Edward F., James and Alice Chen Professor of Radiology, Pathology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering